Down syndrome is the most common autosomal chromosomal disorder with incidence ranging from 1 in 700 to 1:1,000 live births [1]. The protean manifestation are mental retardation, congenital heart disease, and risk for early death. The predominant cause of death is related to the congenital heart defects followed by hypothyroidism, respiratory infections, and malignancy (particularly, leukemia) ...

Background: Acute lymphoblastic leukemia (ALL) is the most common type of leukemia among children. Immunoglobulin A is the most numerous immunoglobulin isotype in mucosal secretion.  Immunoglobulin A (IgA) deficiency can increase risk of cancer in patients. Since few studies have been done on relation between serum IgA and ALL, this study was attempted to evaluate serum IgA in ALL patients...

Acute lymphoblastic leukemia (ALL) in infants under 12 months of age accounts for about 4% of childhood ALL and differs from ALL in older children with respect to immunophenotypic, cytogenetic and molecular genetic features. In contrast to the predominance of male sex in older children with ALL, there is a slight predominance of girls in infant ALL (1). In infant leukemia, all necessary genetic...

introduction nausea and vomiting are the most common side effects of chemotherapy in the pediatrics with cancer which affect their quality of life. use of some methods of complementary medicine in leukemia patients is problematic. because, leukemia patients are at risk of infection and bleeding, therefore the use of acupressure, acupuncture, and deep massage can be risky in these patients. slow...

In recent pediatric trials of acute myeloid leukemia (AML), children with Down syndrome (DS) have had significantly more megakaryoblastic leukemia and have experienced better outcome than other children. To further characterize AML in DS, Children’s Cancer Group Studies 2861 and 2891 prospectively studied demography, biology, and response in AML and myelodysplastic syndrome (MDS) of children wi...

Primary bone marrow blasts from 4 children with t(8;21) acute myeloid leukemia (AML), 6 children with inv(16) AML, and 2 children with t(9;11) AML were injected intravenously or transplanted under the kidney capsule of sublethally irradiated mice with severe combined immunodeficiency (SCID). Leukemic cells from all AML patients infiltrated the SCID mouse thymus, suggesting that the thymic micro...

BACKGROUND In Chile, leukemia is one of the diseases whose treatment is guaranteed by a special law called AUGE (universal access and explicit guaranties). Therefore, the knowledge of its treatment costs is of utmost importance. AIM To determine and to characterize the direct costs of pharmacotherapy for leukemia at a regional hospital in Chile. MATERIAL AND METHODS Data were retrospectivel...

In recent pediatric trials of acute myeloid leukemia (AML), children with Down syndrome (DS) have had significantly more megakaryoblastic leukemia and have experienced better outcome than other children. To further characterize AML in DS, Children's Cancer Group Studies 2861 and 2891 prospectively studied demography, biology, and response in AML and myelodysplastic syndrome (MDS) of children wi...

The frequency of HAV, HBV, HCV and HDV infections were evaluated in children with thalassemia haematologic by ELİSA. A total 136 serum specimens tested for this purpose. Hepatitis B surface antigen (HBsAg) positivity was found 46 % patients leukemia, 50 lymphoma 16.6 thalassemic children. Anti present 8 leukeınia group group. our opinion, vira! hepatitis that have a great prevalence multitransf...