Polyhydroxylated pyrrolidines, such as biologically important azafuranoses represented by the natural product (+)-2,5-imino-2,5,6-trideoxy-gulo-heptitol and its C(3)-epimer, were elaborated from a commercially available enantiomerically pure (2R)-hydroxymethylaziridine by highly stereoselective directed reactions in more than 61% overall yield. At first, the nucleophile 2-trimethylsilyloxyfuran...

trifluoromethylated organic compounds, especially chiral quaternary alcohols bearing trifluoromethyl group are of important intermediates in drugs, agrochemicals and etc.an efficient epoxidation of β-cf3-β,β-disubstituted unsaturated ketones (6) has been developed with environmental benign hydrogen peroxide as the oxidant and f5-substituted chiral quaternary ammonium salt (1g or 5) derived from...

Starting from nitroarenes, under hydrosilylation conditions, using a well-defined N-heterocyclic carbene iron(0) catalyst, (IMes)Fe(CO)4, the corresponding aniline derivatives were produced in 61–92% isolated yields. More impressively, selective synthesis of cyclic amines such as pyrrolidines, piperidines and azepanes conducted levulinic acid, 1,5- 1,6-keto acids, respectively. The sequential p...

(-)-Gephyrotoxin-223 was formally synthesized from chiral synthon 1 which has been chemoenzymatically synthesized  in the presence  of Candida Antartica lipase.        

in the first part of this work, correlation between optical activity and elements of magnetic susceptibility tensor (mst) for five classes of model small molecules containing a single chiral center has been studied using quantum computational techniques at dft-b3lyp level of theory with 6-311g basis set. several molecular properties are used to reduce the mst elements prior to the examination o...

one-pot, four-component procedure for the synthesis of a small library of new chiral spiro- oxindolopyrrolidines with high regio-, diastereo- (>99:1 dr), and enantioselectivity (up to 80% ee) is described. in this process, the regio- and stereochemical 1,3-dipolar cycloaddition of azomethine ylides, which were generated insitu by the reaction of isatin derivatives and sarcosin,with optically ac...

In this paper, the propagation of electromagnetic waves through an infinite slab of uni- or bi- axial chiral medium is analytically formulated for an arbitrary incidence using 4×4 matrix method. In this powerful method, a state vector differential equation is extracted whose solution is given in terms of a transition matrix relating the tangential components of electric and magnetic fields at t...

due to high resolution power of sulfated cyclodextrins (hs-cds), utilization of these selectors for chiral resolution of 7 basic and 2 zwitterionic drugs have been examined. experiments were performed on a hp3dce instrument equipped with an on-column diode array uv absorbance detector. fused silica capillaries with an inner diameter of 50 ?m, an outer diameter of 365 ?m, and a total length of 4...

The front cover picture illustrates a rapid and neat process that enables fluoroalkyl iodides coupling of N,N-diallylamine to construct wide variety fluoroalkylated pyrrolidines through visible-light-induced synthetic process. In this reaction system, the substrate acted both as base electron donor. Details can be found in Communication by Shi-Ji Xiao, Liang Zhao, Chun-Yang He, co-workers (T. M...