Inhibition of the MDM2-p53 protein-protein interaction is being actively pursued as a new anticancer therapeutic strategy, and spiro-oxindoles have been designed as a class of potent and efficacious small-molecule inhibitors of this interaction (MDM2 inhibitors). Our previous study showed that some of our first-generation spiro-oxindoles undergo a reversible ring-opening-cyclization reaction th...

spiro-4- thiazolidinones have been synthesized by the cyclocondensation of phthalazinyl hydrazones with cyclic ketones and substituted mercapto acetic acids. compounds were screened for their antibacterial, antifungal and antihypertensive activity. the combined elemental analyses and spectroscopic data prove the authenticity of the synthesized compounds

An efficient and practical approach for the synthesis of all four stereoisomers of the MT(2) melatonin receptor ligand 4-phenyl-2-propionamidotetralin (4-P-PDOT), each in enantiomerically pure form (ee > 99.9%), was developed. The strategy involved an optical resolution procedure of the key precursor (±)-4-phenyl-2-tetralone with the unusual resolving agent (S)-mandelamide, through the formatio...

In this paper, the pore filling of spiro-OMeTAD (2,2(,7,7(-tetrakis-(N,N-di-pmethoxyphenylamine)9,9(-spirobifluorene) in mesoporous TiO2 films is quantified for the first time using XPS depth profiling and UV–Vis absorption spectroscopy. It is shown that spiro-OMeTAD can penetrate the entire depth of the film, and its concentration is constant throughout the film. We determine that in a 2.5-mm-...

A series of twenty new N-[(4-arylpiperazin-1-yl)-propyl]-2-aza-spiro[4.4]nonane- and [4.5]decane-1,3-dione derivatives were synthesized and their anticonvulsant activity was evaluated in maximal electroshock (MES) and sc pentertazole (sc PTZ) tests. Their neurotoxicity was examined as well. Although no antiseizure properties of the investigated compounds were found in the MES model, eight of th...

Sulfonic acid functionalized SBA-15 (SBA-Pr-SO3H) with pore size 6 nm as an efficient heterogeneous nanoporous solid acid catalyst exhibited good catalytic activity in the Biginelli-like reaction in the synthesis of spiroheterobicyclic rings with good yield and good recyclability. Spiro-pyrimidinethiones/spiro-pyrimidinones-barbituric acid derivatives were synthesized in a simple and efficient ...

A series of organic electron-rich π-bridged symmetric hydrazones, composed two donor moieties connected through a thiophene- or pyrrole-based π-spacer, has been synthesized as suitable alternative to 2,2’,7,7’-tetrakis[N,N-di(4-methoxyphenyl)amino]-9,9’-spirobifluorene (Spiro-OMeTAD), considered the benchmark hole transporting material (HTM) in perovskite solar cells (PSCs). The cheap synthetic...

The algebra of monodromy matrices for sl(n) trigonometric R-matrix is studied. It is shown that a generic finite-dimensional polynomial irreducible representation of this algebra is equivalent to a tensor product of L-operators. Cocommutativity of representations is discussed and inter-twiners for factorizable representations are written through the Boltzmann weights of the sl(n) chiral Potts m...

Lasing in induced cholesteric liquid crystal (CLC) containing highly photosensitive azo chiral dopant (ChD) and pyrromethene laser dye was investigated. Due to the absence of excitation energy transfer from the dye molecules to the molecules of ChD in such a system, a low lasing threshold was achieved. When using violet and green light-emitting diodes, reversible frequency tuning was obtained i...