نتایج جستجو برای: chitosan hydrogels

تعداد نتایج: 27111  

2016
Zhao Wei Jingyi Zhao Yong Mei Chen Pengbo Zhang Qiqing Zhang

Self-healing injectable hydrogels can be formulated as three-dimensional carriers for the treatment of neurological diseases with desirable advantages, such as avoiding the potential risks of cell loss during injection, protecting cells from the shearing force of injection. However, the demands for biocompatible self-healing injectable hydrogels to meet above requirements and to promote the dif...

2017
Ting-Ting Yang Yuan-Zheng Cheng Meng Qin Yong-Hong Wang Hong-Li Yu An-Lin Wang Wei-Fen Zhang

Thermosensitive hydrogels have increasingly received considerable attention for local drug delivery based on many advantages. However, burst release of drugs is becoming a critical challenge when the hydrogels are employed. Microspheres- (MS-) loaded thermosensitive hydrogels were thus fabricated to address this limitation. Employing an orthogonal design, the spray-dried operations of tenofovir...

2014
Luiza A Frank Giuseppina Sandri Francesca D’Autilia Renata V Contri Maria Cristina Bonferoni Carla Caramella Alejandro G Frank Adriana R Pohlmann Silvia S Guterres

The vaginal route of administration is an alternative for several treatments for either local or systemic pharmacological effects. However, the permanence of a drug in this route represents a challenge for formulation development that can be overcome by using nanoencapsulation and chitosan gel. Thus, this work aimed to evaluate the performance of chitosan hydrogels containing cationic and anion...

Journal: :Water 2022

For improving the mechanical strength of controlled release fertilizer (CRF) hydrogels, a novel material Chlorella was employed as bio-based filler to prepare chitosan–chlorella hydrogel beads with physical crosslink method. Here, synthesis mechanism investigated, and exhibited enhanced stability under centrifugation sonication than pure chitosan beads. brought more abundant functional groups o...

Journal: :Tissue engineering 2005
Fackson Mwale Mihaela Iordanova Caroline N Demers Thomas Steffen Peter Roughley John Antoniou

Degenerative disc disease has been implicated as a major component of spine pathology. However, although biological repair of the degenerate disk would be the ideal treatment, there is no universally accepted scaffold for tissue engineering of the intervertebral disk. To help remedy this, we investigated the gelation kinetics of various concentrations (2.5 to 10%) of two water-soluble chitosan ...

2017
Pengfei Chen Sheng Mei Chen Xia Ren Zhu Yichuan Pang Jiying Wang Jianfeng Zhang Fangchun Shao Shunwu Fan

The present study aimed to investigate the synergistic therapeutic effect of decreaseing cartilage angiogenesis via exposure to crizotinib encapsulated by chitosan microspheres and photo-crosslinked hydrogel, with the goal of evaluating crizotinib as a treatment for osteoarthritis. First, we developed and evaluated the characteristics of hydrogels and chitosan microspheres. Next, we measured th...

2012
Owen Im Jian Li Mian Wang Lijie Grace Zhang Michael Keidar

BACKGROUND Many shortcomings exist in the traditional methods of treating bone defects, such as donor tissue shortages for autografts and disease transmission for allografts. The objective of this study was to design a novel three-dimensional nanostructured bone substitute based on magnetically synthesized single-walled carbon nanotubes (SWCNT), biomimetic hydrothermally treated nanocrystalline...

Journal: :Journal of Materials Science: Materials in Medicine 2004

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