The behavioral mechanisms underlying antipsychotic-induced maternal behavior deficits were examined in the present study. Different groups of postpartum rats were treated with haloperidol (0.1 mg/kg), clozapine (10.0 mg/kg), chlordiazepoxide (5.0 mg/kg, an anxiolytic) or vehicle (0.9% saline) on Days 4 and 6 postpartum and their maternal behaviors were tested under either pup-separation (e.g. p...

A double-blind controlled comparison of four commonly-used tranquillizing drugs (haloperidol, amylobarbitone sodium, chlordiazepoxide, and trifluoperazine) against placebo was made in their effects on the performance of volunteers during three low speed vehicle-handling tests. The drugs (with the exception of haloperidol) significantly altered driving behaviour though they did not seem to inter...

By using operant conditioning techniques one group of 8 rats was trained to reach through a hole in the wall of an operant chamber, and to exert downward responses on a force-sensing circular disk. Eight other rats learned to reach through the hole and grasp and pull toward them a wire bail attached to a force transducer. Both behaviors were maintained on a fixed ratio 20 schedule of water rein...

The benzodiazepines have now been available to the clinician for over 20 years, since the introduction of chlordiazepoxide (Librium) in 1960. The broad and unique spectrum of activity of these compounds as anxiolytics, hypnotics/sedatives, anticonvulsants and muscle relaxants, together with their low toxicity and an essential absence from peripheral side-effects, has resulted in compounds of th...

A multicenter double-blind placebo-controlled study of cytidine 5'-diphosphocholine (CDP-choline) was conducted to evaluate possible clinical benefits of the drug in patients with acute, moderate to severe cerebral infarction. The patients included also suffered from moderate to mild disturbances of consciousness, and all were admitted within 14 days of the ictus. Patients were allocated random...

Antipsychotic drugs selectively suppress conditioned avoidance response. Using a two-way active avoidance response paradigm, we examined the role of drug-induced interoceptive state in the mediation of avoidance-suppressive effect. In Experiment 1, we found that rats intermittently treated with olanzapine (OLZ) (1.0 mg/kg, s.c.) or haloperidol (0.03 mg/kg, s.c.) on the 1st day of a 3-day cycle ...