Alcohol abuse is associated with increased lung infections. Molecular understanding of the underlying mechanisms is not complete. Airway epithelial ion transport regulates the homeostasis of airway surface liquid, essential for airway mucosal immunity and lung host defense. Here, air-liquid interface cultures of Calu-3 epithelial cells were basolaterally exposed to physiologically relevant conc...

The brain is a complex organ with active components composed largely of neurons, glial cells, and blood vessels. There exists an enormous experimental and theoretical literature on the mechanisms involved in the functioning of the brain, but we still do not have a good understanding of how it works on a gross mechanistic level. In general, the brain maintains a homeostatic state with relatively...

Hybrid gel polymer electrolytes (HGPEs) based on polymethyl methacrylate (PMMA)-polylactic acid (PLA) doped with LiTFSI and incorporated 1-butyl-3-methylimidozalium chloride (BmimCl) were successfully prepared. The complexes of the HGPEs different BmimCl contents characterized via Fourier transform infrared (FTIR) X-ray diffraction (XRD) analysis. Based impedance spectroscopy analysis, composit...

The injection of tetraethylammonium chloride into the giant axon of the squid prolongs the action potential and eliminates most of the late current under voltage-clamp. Experiments on fibers in an external medium of high potassium ion concentration demonstrate that injected tetraethylammonium chloride causes rectification of the instantaneous current-voltage curve for potassium by excluding out...

In the title compound, [MnCl(2)(C(11)H(13)N(5))], the Mn(II) ion is five-coordinated in a distorted square-pyramidal geometry, with three N atoms from the neutral tridentate 2,6-bis-(4,5-dihydro-1H-imidazol-2-yl)pyridine ligand and one chloride ion forming the basal plane and the other chloride ion in the apical position. Both dihydro-imidazole rings adopt envelope conformations. In the crystal...

The asymmetric unit of the title compound, [NiCl(2)(C(10)H(14)N(4))(2)](n), consists of one Ni(2+) ion which is located on an inversion center, one 1,4-bis-(imidazol-1-yl)butane (bimb) and one chloride ion. The Ni(2+) ion exhibits a distorted octa-hedral coordination environment defined by four N atoms from four bimb ligands in the equatorial plane and two chloride ions in axial positions. The ...

A hypothesis was tested in this study that antagonists of adrenergic and cholinergic receptors affect sodium and chloride ion transport in the rabbit caecum. A modified Ussing chamber was used in the experiment. It was demonstrated that isolated caecum responded to a mechanical stimulus, which consisted in gentle rinsing of the mucous surface, with changes in transepithelial electrical potentia...