The effects of cholecystokinin (CCK) receptor antagonists on hypothermia
induced by cocaine or morphine have been studied in mice. In the present work,
subcutaneous (SC) injection of cocaine (50-150 mg/kg) or morphine (125-500
mg/kg) induced hypothermia in mice. Administration of CCKA receptor antagonist
MK-329 (0.5-1.5 mg/kg), CCKB receptor antagonist L-365, 260 (0.5-1.5 mgl
kg) and CCK r...