Cholinesterase Activity in Female Greenhouse Workers—Influence of Work Practices and Use of Oral Contraceptives: Jesper B NIELSEN, et al. Environmental Medicine, University of Southern Denmark—Objectives—Associations between serum butyryl cholinesterase activity in female greenhouse workers and information from a questionnaire on work, use of personal protective equipment, and lifestyle were ev...

exist for cholinesterase assay, but each has drawbacks (1, 2). This paper presents an improved version of Garry and Routh's modification (3) of Ellman's method, as well as variations of this method for the assay of " true " cholinesterase in red cells and for the determination of the dibucaine number. The basic reactions are: Milwaukee, Wis. 53233), 2.0 mg/mI in 0.2 molar potassium phosphate bu...

Background We investigated the effect of cholinesterase inhibitors on all-cause discontinuation, efficacy and safety, and the effects of study design-, intervention-, and patient-related covariates on the risk-benefit of cholinesterase inhibitors for Alzheimer's disease. Methods A systematic review and meta-analysis of randomized placebo-controlled clinical trials comparing cholinesterase inh...

The presence of enzymes in mammalian blood which hydrolyze acetylcholine was first suspected by Dale (1)) and later demonstrated by Plattner (2) and by Engelhart and Loewi (3). A serum cholinesterase isolated by Stedman et al. (4) from horse blood was first thought to be the same as the cholinesterase in the central nervous system.’ Distinct differences between the cholinesterase of erythrocyte...

BACKGROUND The prescribing cascade model involves the misinterpretation of an adverse reaction to 1 drug and the subsequent, potentially inappropriate prescription of a second drug. We present a new example of the prescribing cascade involving cholinesterase inhibitors and anticholinergic drugs used to manage urinary incontinence. METHODS A population-based retrospective cohort study was carr...

The cholinesterase activity of skeletal muscle and its subcellular components, including motor endplates, was compared chemically in human, mouse and rat. The total cholinesterase activity of muscle per unit protein was in the descending order of human, mouse and rat. Cholinesterase was present in all subcellular components fractionated by differential centrifugation, and was greatest in the mi...

Propranolol, a widely used beta-blocker, inhibits the hydrolysis reaction of enzyme cholinesterase. Measurements of the difference in rate of hydrolysis rate between uninhibited and inhibited reactions allow the development of a kinetic method for its determination. Both systems, enzyme–substrate–chromogen and enzyme–substrate–chromogen–inhibitor, were characterized through biochemical kinetic ...