Background: Cerebrospinal fluid (CSF) ascites is an abnormal accumulation of CSF within the peritoneal cavity caused by peritoneum's inability to absorb CSF, following a ventriculoperitoneal (VP) shunt surgery. Excessive production (e.g, choroid plexus papilloma and villous hypertrophy), high protein secondary chronic infection (e.g. tuberculosis), brain tumours optic gliomas craniopharyngiomas...

The choroid plexus, which is responsible for the maintenance of the biochemical milieu of the cerebrospinal fluid (CSF), avidly sequesters Pb. In order to test the hypothesis that chronic Pb exposure may impair choroid plexus function, male weanling Sprague-Dawley rats were exposed to Pb in drinking water at doses of 0, 50, or 250 micrograms Pb/ml (as Pb acetate) for 30, 60, or 90 days. The fun...

1. Lignocaine readily passes from blood into cerebrospinal fluid. The isolated rabbit choroid plexus, a locus of the blood-cerebrospinal fluid barrier, accumulated [14C]lignocaine by two processess: an active, saturable transport process and a non-saturable process. 2. The accumulation of [14C]lignocaine by choroid plexus was not due to non-specific binding or metabolism of lignocaine within or...