A girl aged 21⁄2/ years with Moebius syndrome was found to have a deletion of band q12.2 in chromosome 13 (46,XX,del(13Xq12.2)). This is the second report concerning involvement of chromosome 13q and Moebius syndrome. The observation raises the possibility that a gene responsible for Moebius syndrome is located in this region of chromosome 13. Moebius syndrome (MS) consists of congenital facial...

To assess the frequency and significance of nonrandom abnormalities of chromosome 9p in childhood acute lymphoblastic leukemia (ALL), we analyzed our experience with 398 consecutive cases with completely banded karyotypes. Forty cases (10%) with abnormalities of 9p were identified: 26 with deletions, nine with unbalanced translocations resulting in the loss of 9p material, and five with apparen...

Background and Aims: Detection of overexpression in tumor-inhibiting genes provides valuable information for leukemia diagnosis and prognosis. Chronic myeloid leukemia (CML) is a stem cell disorder determined by a well-defined genetic anomaly involving BCR-ABL translocation in the Philadelphia chromosome. Curcumin is a chemo-preventive agent for the primary cancer targets, such as the breast, p...

Chromosome studies were done on 82 patients with multiple myeloma, 11 with amyloidosis, 2 with multiple myeloma and amyloidosis, and 5 with plasma cell leukemia to investigate their chromosomal abnormalities and to determine the usefulness of cytogenetic studies. A chromosomally abnormal clone was found in 29 patients but was observed most often in those with active disease: in 18% of patients ...

Congenital corneal opacification (CCO) encompasses a broad spectrum of disorders that have different etiologies, including genetic and environmental. Terminology used in clinical phenotyping is commonly not specific enough to describe separate entities, for example both the terms Peters anomaly and sclerocornea have been ascribed to a clinical picture of total CCO, without investigating the pre...

Caryological studies were carried out on ten species of the genus Suaeda belonging to 27 samples of different populations in Iran. Important chromosome features including numbers, lengths, centromere locations and caryotypes were studied. All the species have basic chromosome numbers of x=9. Chromosome counts of S. acuminata (C.A.Mey.) Moq. (2n=18), S. aegyptiaca (Hasselq.) Zoh., (2n=l8)...

This paper reports on the karyotyping of mullet fish species, Liza klunzingeri, endemic of the Persian Gulf. The metaphase chromosome spreads, obtained from kidney cells of 13 specimens were examined. The diploid chromosome number was found to be 2n=48. The karyotype was discovered to be consisted of 48 acrocentric chromosome pairs. The arm number was determined to be NF=48. The chromosome numb...

Erodium (Geranaiceae) species are distributed in different habitats of Iran. Some species are of medicinal importance while some are well known weeds. There are no chromosome counts for Erdoium species of Iran. Chromosome numbers are given for six taxa of Erodium (Geraniaceae) from Iran: E. cicutarium (2n=36), E. ciconium(2n=18), E. malacoides (2n=20), E. moschatum (2n=20), E. neuradifolium (2n...

The combination of cytoplasmic male sterility (CMS) in one parent and a restorer gene (Rf) to restore fertility in another are indispensable for the development of hybrid varieties. To genotype rice lines at the restoring fertility (Rf) loci, 38 lines were crossed with a sterile tester (rfrf) line. Pollen fertility test was performed to identify sterile and fertile F1 hybrids. Seven lines were ...

The tribe Sophoreae sensu Polhill [9,10] is a large and diverse assemblage comprising the ancient and primitive ancestral stocks of Papilionoideae. The most frequent chromosome basic numbers in this tribe are x = 11 and x = 9 but chromosome numbers range from x = 8-14 are also known. In this study chromosome numbers and karyotype variation of Iranian members of tribe Sophoreae are reported. Ira...