نتایج جستجو برای: chromosome duplication
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Abstract Background Cannabis, an important industrial crop, has a high sensitivity to photoperiods. The flowering time of cannabis is one its agronomic traits, and significant effect on yield quality. CONSTANS-like ( COL ) gene plays key role in the regulation this plant. However, specific roles family are still unknown. Results In study, 13 CsCOL genes were identified genome. Phylogenetic anal...
Genome sequencing of the model legumes, Medicago truncatula and Lotus japonicus, provides an opportunity for large-scale sequence-based comparison of two genomes in the same plant family. Here we report synteny comparisons between these species, including details about chromosome relationships, large-scale synteny blocks, microsynteny within blocks, and genome regions lacking clear corresponden...
Although the etiology of autism remains largely unknown, cytogenetic and genetic studies have implicated maternal copy number gains of 15q11-q13 in 1-3% of autism cases. In order to understand how maternal 15q duplication leads to dysregulation of gene expression and altered chromatin interactions, we used microcell-mediated chromosome transfer to generate a novel maternal 15q duplication model...
I T HAS BECOME clear in recent years that malignant clones often exhibit chromosome abnormalities, and that these acquired abnormalities are often highly specific for a particular type of tumor. Translocations, as well as deletions of entire chromosomes or of specific regions, are well-known findings in chronic myelogenous leukemia, meningioma, and retinoblastoma, for example. Disturbances of c...
Duplications are often attributed to "unequal recombination" between separated, directly repeated sequence elements (>100 bp), events that leave a recombinant element at the duplication junction. However, in the bacterial chromosome, duplications form at high rates (10(-3)-10(-5)/cell/division) even without recombination (RecA). Here we describe 1800 spontaneous lac duplications trapped nonsele...
Complex chromosome rearrangements (CCRs), which are rather rare in the whole population, may be associated with aberrant phenotypes. Next-generation sequencing (NGS) and conventional techniques, could be used to reveal specific CCRs for better genetic counseling. We report the CCRs of a girl and her mother, which were identified using a combination of NGS and conventional techniques including G...
The mouse BCM1 (OX45, Blast-1) antigen has been cDNA cloned and sequenced to provide data supporting the view that BCM1, LFA3, and CD2 constitute a subgroup within the Ig superfamily. Mouse BCM1 is widely expressed on leukocytes and is likely to be anchored to the cell surface by a glycosyl-phosphatidylinositol anchor, as is the case for rat and human BCM1 antigen. Genetic linkage studies by re...
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