Previous studies from our laboratory have suggested that degenerin proteins contribute to myogenic constriction, a mechanism of blood flow regulation and protection against pressure-dependent organ injury, in renal vessels. The goal of the present study was to determine the importance of one family member, acid-sensing ion channel 2 (ASIC2), in myogenic constriction of renal interlobar arteries...

Background: Damages to the peripheral fibers of sensory nerve cells and central neurons cause neuropathic pain. Manifestations pain occur in various conditions, including diabetes mellitus, chemotherapy, as side effects some medications. Cressa cretica has long been used traditional medicine for control. This study was conducted determine role opioid receptors analgesic effect hydroalcoholic ex...

introduction: pharmacological blockage of glial activity has been proved useful for treatment of neuropathic pain by lowering proinflammatory cytokines. the present study is to confirm the effect of post-injury administration of pentoxifylline on chronic constriction injury (cci)-induced neuropathic pain symptoms_ and improved the efficacy of morphine anti-nociception. methods: male wistar rats...

In the present study, the rat sciatic nerve was constricted to varying degrees using only one ligature with a very thin polyethylene sheath placed between nerve and ligature thread. Complete nerve transection was studied for comparison. With a 40-80% constriction of the nerve we observed allodynia to a similar extent as in the so-called Bennett model based on four loose ligatures. We also monit...

Purpose: To investigate the role of RAS-like protein A (RalA) in lipopolysaccharide-induced inflammatory regulation primary microglia chronic constriction injury (CCI)-induced neuropathic pain rat models.
 Methods: In vitro, overexpression (OE) RalA was performed using transfection procedure, and then LPS used to provoke phenotype. vivo, model induced CCI treated with LV-RalA. Neuroinflamm...

BACKGROUND Patients suffering chronic pain are at high risk of suffering long-lasting emotional disturbances characterized by persistent low mood and anxiety. We propose that this might be the result of a functional impairment in noradrenergic circuits associated with locus coeruleus (LC) and prefrontal cortex, where emotional and sensorial pain processes overlap. METHODS We used a chronic co...

BACKGROUND Mu opioid receptor (MOR) plays a crucial role in mediating analgesic effects of opioids and is closely associated with the pathologies of neuropathic pain. Previous studies have reported that peripheral nerve injury downregulates MOR expression, but the epigenetic mechanisms remain unknown. OBJECTIVE Therefore, we investigated DNA methyltransferase3a (DNMT3a) expression or methylat...