Background Camurati-Engelmann disease (CED) is a rare osteosclerotic autosomal dominant condition responsible for chronic diaphyseal pain. It caused by mutations of Tumor Growth Factor β1 (TGFβ1 ) gene. Currently there are no validated therapies this condition. Objectives To test the efficacy anti-TNFα antibody in patient affected CED. Methods Etanercept 50 mg per week was administered with Dat...

Contraversive eye deviation (CED) is most often observed intraoperatively during subthalamic nucleus implantation for Parkinson's disease and considered to result from wrong electrode positioning. We report on a woman, bilaterally implanted in the subthalamic nucleus for severe Parkinson's disease disclosing long-lasting CED only when the stimulators were activated separately. Clinical examinat...

During apoptosis, phosphatidylserine (PS), normally restricted to the inner leaflet of the plasma membrane, is exposed on the surface of apoptotic cells and serves as an 'eat-me' signal to trigger phagocytosis. It is poorly understood how PS exposure is activated in apoptotic cells. Here we report that CED-8, a Caenorhabditis elegans protein implicated in controlling the kinetics of apoptosis a...

Camurati-Engelmann disease (CED) is a rare autosomal dominant bone disorder caused by a mutation in transforming growth factor β1 (TGFβ1). The present study aimed to identify a Chinese family with suspected CED based on the clinical symptoms, including pain in extremities, waddling gait, muscle weakness, cortical thickening of the diaphysis of the long bones, and sclerosis of the skull, facial ...

Recent progress in nanotechnology and electrochemical methods can be applied to fine control of the size, crystal structure, and surface properties of iron oxide nanoparticles. Here we appliedcathodic electrochemical deposition (CED) as an efficient and effective tactic for synthesisand double coating of surface of superparamagnetic iron oxide nanoparticles (SPIONs). In first step, bare Fe3O4 n...

A general approach to the design of accurate classical potentials for protein folding is described. It includes the introduction of a meaningful statistical measure of the differences between approximations of the same potential energy, the definition of a set of Systematic and Approximately Separable and Modular Internal Coordinates (SASMIC), much convenient for the simulation of general branc...

Programmed cell death, or apoptosis, is important in the development and homeostasis of metazoans. In the nematode C. elegans, four genes, egl-1, ced-9, ced-4, and ced-3, constitute the core pathway acting in all somatic programmed cell deaths. This pathway is evolutionarily conserved in humans. The BH3-only protein EGL-1 is transcriptionally upregulated in cells fated to undergo programmed cel...

A century ago, dietary fat was mainly seen as a source of energy. In 1929, George and Mildred Burr introduced the concept of essential fats: certain fats, i.e. linoleic acid and alpha-linolenic acid, need to be provided by the diet to prevent deficiencies. Although essential fats were initially considered of marginal nutritional importance for humans, clinical deficiency symptoms were recorded ...

Objective To compare the effects of Pars Plana Vitrectomy (PPV) and Scleral Buckling (SB) with reference to Central Corneal Thickness (CCT), Corneal Endothelial-Cell Density (CED), Anterior Chamber Depth (ACD) and Axial Length (AL) in repair of Rhegmatogenous Retinal Detachment (RRD). Methods This comparative cross sectional analytical study was conducted at Armed Forces Institute of Ophthalm...

INTRODUCTION In mammals, spermatogenesis is a multistep processes, comprising mitotic proliferation of spermatogonia, meiotic division of spermatocytes and maturation of haploid spermatids (Nakanishi and Shiratsuchi, 2004). As spermatids undergo terminal differentiation into spermatozoa, the bulk cytoplasmic contents are segregated into the residual body, which is sloughed off, phagocytosed and...