introduction: autosomal dominant polycystic kidney disease (adpkd) is one of the most common genetic kidney disorders with the incidence of 1 in 1,000 births. adpkd is genetically heterogeneous with two genes identified: pkd1 (16p13.3, 46 exons) and pkd2 (4q21, 15 exons). eighty five percent of the patients with adpkd have at least one mutation in the pkd1 gene. genetic studies have demonstrate...

Uric acid, the end-product of purine metabolism in humans, is not only a cause gout, but also may play roles developing cardiovascular diseases such as hypertension, atrial fibrillation, chronic kidney disease, heart failure, coronary artery and death. Several clinical investigations have reported serum uric acid predictive marker for outcomes. Although causal relationship hyperuricemia to rema...

BACKGROUND Glomerular and interstitial macrophage infiltration is a feature for both the acute and chronic kidney diseases. Macrophages have been shown to play a diverse role in kidney injury and repair. Thus, macrophages may be a key cell type in acute and chronic kidney injury and repair. SUMMARY AND KEY MESSAGES During renal inflammation, circulating monocytes are recruited and then become...

Background and Objective: The COVID-19 pandemic is a phenomenon that has infected and killed many people worldwide. Underlying diseases such as diabetes mellitus, heart failure, and chronic kidney disease (CKD) can affect the severity of COVID-19 and aggravate patients' condition. This study aimed to predict the severity of the COVID-19 disease in CKD patients by combining feature selection and...

Chronic kidney disease is associated with progressive kidney fibrosis, which disrupts normal kidney function. There is a great need for treatments to reduce renal fibrosis. In this issue of the JCI, Ito and colleagues report the development of synthetic ligands of the vitamin D receptor that target the TGF-β-SMAD signaling pathway, which is known to regulate fibrosis-associated gene expression,...

Today, adipokines are important cellular signaling proteins synthesized by adipose tissue and involved in a variety of processes, including inflammation, lipid glucose metabolism, insulin sensitivity, endothelial cell function, angiogenesis, blood pressure regulation, many others. This review examines the immunological endocrine function omentin its potential use as biomarker therapeutic target...

Branching morphogenesis in the kidney is a tightly regulated, complex process and its disruption potentially can lead to a broad spectrum of diseases, ranging from rare hereditary syndromes to common conditions such as hypertension and chronic kidney failure. This review synthesizes data on branching during kidney development derived from in vitro and in vivo rodent studies and to apply them to...

background few studies have focused on patients’ characteristics that affects acute kidney injury (aki) after total knee replacement surgery (tkr). objectives the primary objective of this retrospective study was to identify patients’ characteristics associated with aki after tkr. patients and methods between january 2008 and december 2009, 659 patients with a mean age of 67.1 years (range, 39-...

As the number of individuals with non-alcoholic fatty liver disease (NAFLD) has increased, the influence of NAFLD on other metabolic diseases has been highlighted. Accumulating epidemiologic evidence indicates that NAFLD not only affects the liver but also increases the risk of extra-hepatic diseases such as type 2 diabetes mellitus, metabolic syndrome, dyslipidemia, hypertension, cardiovascula...

The spectrum of infection-related kidney diseases (IRKD) is diverse resulting from either direct invasion or indirectly by immune-mediated mechanisms nephrotoxic effects antimicrobial agents used for treatment. IRKD can manifest in form several renal clinical syndromes: acute injury (AKI), and chronic glomerulonephritis syndrome, nephrotic syndrome etc. common developing countries but the data ...