BACKGROUND We previously reported that allanxanthone C and macluraxanthone, two xanthones purified from Guttiferae trees, display in vitro antiproliferative and proapoptotic activities in leukemic cells from chronic lymphocytic leukemia (CLL) and leukemia B cell lines. RESULTS Here, we investigated the in vivo therapeutic effects of the two xanthones in a xenograft murine model of human CLL, ...

CLL: chronic lymphocytic leukemia PR: pityriasis rosea EGFR: epidermal growth factor receptor PDGFR: platelet-derived growth factor receptor I brutinib, a Bruton tyrosine kinase inhibitor, is a new oral agent approved for the treatment of chronic lymphocytic leukemia (CLL). Ibrutinib is well-tolerated, with the majority of its adverse events within grade 1 or 2 severity. The most common nonhema...

It is unclear if this is a direct effect or mediated by kinase inhibition. Sphingolipids are also known as mediators of mitochondrial apopto-sis. Consistent with the antiapoptotic effect of glucosylceramide, BCR stimulation reduced the effect of the mitochondria-targeting drug ABT-737. Concomitant treatment with low doses of the kinase (and apparently UGCG) inhibitors GS-1101 and ibrutinib rest...

It has long been speculated that common genetic variation influences the development of B-cell malignancy, however until recently evidence for this assertion was lacking. The advent of genome-wide association studies (GWAS) has allowed the search for this class of susceptibility allele to be conducted on a genome-wide basis. Recent GWAS of chronic lymphocytic leukemia (CLL) and acute lymphoblas...

 Backgrounds: MicroRNAs (miRNAs) have crucial roles in cellular and molecular processes related to different malignancies including chronic lymphocytic leukemia (CLL). In recent years the most studies demonstrated that the expression of miR-95, alter in several diseases. Long non-coding RNAs (lncRNAs) a heterogeneous group of non-coding and regulatory RNAs. The present study investigated the as...

We obtained a monoclonal antibody, A50, after immunizing Biozzi's high responder strain of mice with T cell chronic lymphocytic leukemia (T-CLL) cells. A50 recognized an antigen present on the surface of B cell chronic lymphocytic leukemia cells from many patients and from cells of T lineage from any subject we tested. We could not find this antigen either on the surface of normal B cell or on ...

Over the past two decades, slow but deliberate progress has been made in understanding the genetics of chronic lymphocytic leukemia (CLL) and how the surrounding microenvironment influences leukemia cell survival. The complexity of CLL with respect to different chromosomal aberrations, lack of a common aberrant signaling pathway activation, and associated immune suppression of the disease has b...

Richter transformation (RT) is a condition wherein B cell chronic lymphocytic leukemia (CLL) transforms into more aggressive lymphoma variant. The incidence and the significance of RT detected by 2-[18F]-FDG PET/CT clinical challenge it not widely investigated in literature. aim this systematic review was to analyze published data about potential role detecting RT. A comprehensive computer lite...

background: patients with b-cell chronic lymphocytic leukemia (b-cll) have hetero-geneous clinical courses, thus several biological parameters need to be added to the cur-rent clinical staging systems to predict disease outcome. recent immunophenotypic stud-ies performed mainly in western populations have demonstrated the prognostic value of cd38 and zap-70 expression in b-cll. objectives: to i...

Cholesterol has many critical functions in cells. It is a key component of membranes and cell-signalling processes, it as chemical precursor several biochemical pathways, such Vitamin D steroid synthesis. also been implicated the development progression various cancers, which thought to promote cell proliferation, migration, invasion. Chronic lymphocytic leukemia (CLL) an example lipid-avid can...