OBJECTIVES We sought to evaluate whether coronary collateral flow is clinically relevant for future cardiac ischemic events. BACKGROUND The link between good collateral supply related to less myocardial damage and fewer cardiac events has not been established prospectively beyond doubt. METHODS In 403 patients with stable angina pectoris undergoing percutaneous transluminal coronary angioplasty...

Humans have been found to display considerable variety in their pursuit of mating strategies, varying in their preference for short-term mating encounters versus established long-term relationships. While we know that differences in mating strategy exist between the two sexes (as predicted by parental investment theory), it has recently been shown that each sex may further exhibit two mating ph...

We developed an experimental method to generate mechanically stable (MS) packings of frictionless disks and performed coordinated experiments and simulations to characterize MS packings in small systems. For a given system geometry, MS packings occur as discrete, well-separated points in configuration space with probabilities that vary by many orders of magnitude and are robust with respect to ...

The fractal scaling properties of the heartbeat time series are studied in a controlled ergometric regime using the Hurst rescaled range R/S analysis. The long-time ”memory effect” quantified by the value of the Hurst exponent H > 0.5 is found to increase during progresive physical activity at healthy subjects in contrast to those having stable angina pectoris (SAP), where it is decreasing. We ...

OBJECTIVES The purpose of this study was to determine if ranolazine improves angina in stable coronary patients with persisting symptoms despite maximum recommended dose of amlodipine. BACKGROUND Ranolazine is a unique antianginal agent that has been effective in stable angina, but it has not been studied in the setting of maximum recommended doses of conventional antianginal agents. METHOD...

• Objective: To review the COURAGE trial and other data related to revascularization of patients with asymptomatic or stable coronary artery disease. • Methods: Literature review. • Results: The goals of therapy in patients with stable angina are to alleviate symptoms, prevent future events, and improve survival. This is achieved by a combination of antiplatelet therapy, risk factor modificatio...

BACKGROUND Patients with chronic coronary artery disease exhibit a dysfunctioning endothelium, which may be responsible for exercise-induced platelet activation and expression of a procoagulant moiety. In this study, we evaluated the therapeutic efficacy of a low molecular weight heparin (Parnaparin) in patients with stable angina pectoris. METHODS AND RESULTS According to a double-blind, ran...