BACKGROUND Angiotensin (Ang) II and Ang-(1-7) are two of the bioactive peptides of the rennin-angiotensin system. Ang II is involved in the development of cardiovascular disease, such as hypertension and atherosclerosis, while Ang-(1-7) shows cardiovascular protection in contrast to Ang II. METHODOLOGY/PRINCIPAL FINDINGS In this study, we investigated effects of Ang II and Ang-(1-7) on vascul...

Arterial hypertension represents one of the most common diseases in developed countries and the rennin-angiotensin-aldosterone system is among the major factors in the regulation of blood pressure and sodium balance. With the exception of rare monogenetic diseases, however, inheritance of aldosterone secretion is widely unknown. In this study, we investigated the aldosterone levels in male and ...

Cancer is the leading cause of death worldwide (World Health Organization). Therapeutic strategies usually involve a combination of surgical ablation, radiotherapy and chemotherapy. Apart from conventional chemotherapy, targeting of the tumour vasculature by vascular disrupting agents or inhibitors of angiogenesis has also been used. Several antihypertensive agents have been used to reduce the ...

Antagonism of the rennin-angiotensin-aldosterone-system (RAAS) decreases BP and reduces proteinuria in chronic kidney disease. BP is decreased approximately 5 mmHg when angiotensin II blockers are added to angiotensin-converting enzyme (ACE) inhibitors and is less than typically seen when other agents are added to existing ACE inhibitor regimens. Dual RAAS blockade results in additional reducti...

The changes produced by the action of rennin in milk and solutions of casein have been the subject of many investigations. Fremy’ was probably the first to give an explanation of this phenomenon. He believed the power to coagulate milk possessed by an extract of the mucous lining of a calf’s stomach to be due to the presence of an enzyme which converted some of the lactose of the milk into lact...

CONTEXT Skeletal muscle is comprised of a highly organized network of cells, neurovascular structures, and connective tissue. Muscle injury is typically followed by a well-orchestrated healing response that consists of the following phases: inflammation, regeneration, and fibrosis. This review presents the mechanisms of action and evidence supporting the effectiveness of various traditional and...

Introduction. Opiates are traditionally used for treatment of some acute heart disorders. There are only few reports on the effects of long-term treatment of cardiovascular diseases with morphine. This study aimed to investigate the effects of chronic low-dose morphine use on the cardiovascular system in two-kidney one-clip (2K1C) hypertensive rats. Materials and Methods. Male Wistar rats were ...