BACKGROUND The abnormality of interleukin-21 (IL-21)-IL-21-receptor (IL-21R) system has been found in many autoimmune diseases including autoimmune thyroid diseases (AITDs). In this study, we investigated whether polymorphisms of the IL-21 and IL-21R are associated with Graves' disease (GD) and Hashimoto's thyroiditis (HT), two major forms of AITDs, among a Chinese population. METHODS Rs90771...

the computer simulation program of a practical scale reverse electrodialysis process has been developed based on the program for saline water electrodialysis. the program is applied to compute the performance of an industrial-scale reverse electrodialysis stack (effective membrane area s = 1 m × 1 m = 1 m2, cell pair number n = 300 pairs). the stack operatingconditions are optimized. seawater a...

BACKGROUND AND AIMS IL-is important in gastric damage, mucosal repair and gastric cancer progression. We analysed IL-11 expression in H.pylori infected mouse stomach, the site of gastric IL-11 expression in mice and humans, and the effect of exogenous IL-11 on gastric mucosal homeostasis. METHODS IL-11 protein was localised in mouse and human stomach. The impact of chronic, exogenous IL-11 on...

Background: Patients with ulcerative colitis are at increased risk of inflammation. Interleukin 23 (IL-23) is a newly identified cytokine with increased expression in inflamed biopsies of colon mucosa in patients with Crohn's disease; however, there is inconsistent evidence on its role in ulcerative colitis. Objective: We aimed to compare serum IL-23 level in patients with ulcerative colitis an...

OBJECTIVE We performed a meta-analysis to assess association between interleukin 1 (IL-1) polymorphisms and the risk of Intervertebral Disc Degeneration (IDD). BACKGROUND A series of studies have investigated the association between common single nucleotide polymorphisms in IL-1 and IDD risk; however, the overall results are inconclusive. METHODS Two independent investigators conducted a sy...

abstract introduction: peptic ulcer is a common problem in medicine with serious impacts on the quality of life of patients. it has been shown that helicobacter pylori infection is related with inflammatory responses of gastric mucosa. however, some patients remain asymptomatic. sustained colonization and chronic inflammation increase the risk of gastritis and peptic ulcer. the aim of this stud...

Evidence suggests that immune system alterations in Down syndrome (DS) may be early events that drive neuropathological and cognitive changes of Alzheimer's disease. The primary objective of this meta-analysis was to investigate whether there is an abnormal cytokine profile in DS patients when compared with healthy control (HC) subjects. A systematic search of Pubmed and Web of Science identifi...

Gliomas are aggressive brain tumor. Association studies were consistent for an inverse association between asthma and allergic conditions (IgE levels) and risk of glioma. Studies reported that the IL-4Ra, IL-13 and STAT6 genes played a relatively strong role in IgE production or allergy. This population-based case-control study aimed to find potential association between single nucleotide polym...