Chronic hypoxia likely plays a pivotal role in chronic renal disease, but the specifics of its involvement remain unclear. To elucidate how chronic hypoxia occurs and whether hypoxia participates in the progression of renal disease, the authors established an irreversible glomerulonephritis model induced by uninephrectomy and repeated anti-Thy-1 antibody injections. Glomerulosclerosis with micr...

Capillaries recruit when pulmonary arterial pressure rises. The duration of increased pressure imposed in such experiments is usually on the order of minutes, although recent work shows that the recruitment response can occur in <4 s. In the present study, we investigate whether the brief pressure rise during cardiac systole can also cause recruitment and whether the recruitment is maintained d...

The pecten oculi of the great horned owl (Bubo virginianus) has been examined by light and electron microscopy. The pecten in this species is of the pleated type and is small in comparison to the size of the eyeball. It consists of 7-8 accordion folds which are joined apically by a pigmented bridge of tissue. Within each fold are numerous capillaries, larger supply and drainage vessels and plen...

BURTON, K.. S., AND P. C. JOHNSON. Reactive hyperemia in individual capillaries of skeletal muscle. Am. J. Physiol. 223 (3) : 517-524. 1972.-Red cell velocity profiles in individual capillaries were studied in the sartorius muscle of the cat during reactive hyperemia using a dual-slit photometric system. The velocity profiles varied considerably from each other and from the simultaneously measu...

Abstract Two major obstacles in brain cancer treatment are the blood-tumor barrier (BTB) and quiescent tumor cells. Here we show that Sox2+ cells directly project cellular processes to ensheathe capillaries medulloblastoma (MB), a process depends on mechanosensitive ion channel Piezo2. MB develops tissue stiffness gradient as function of distance capillaries. perceive substrate sustain local in...