The purpose of this study was to investigate the clinical outcome, inflammatory response and myocardial function in high-risk patients undergoing three different leukocyte depletion strategies. Over a four-month period, forty patients (EuroSCORE 6+) undergoing coronary revascularization were prospectively randomized to one of the four perfusion protocols: Group 1 (N=10): Conventional circuits (...

Emerging evidence indicates the beneficial effects of physical exercise on human health, which depends on the intensity, training time, exercise type, environmental factors, and the personal health status. Conventional biomarkers provide limited insight into the exercise-induced adaptive processes. Circulating microRNAs (miRNAs, miRs) are dynamically regulated in response to acute exhaustive ex...

Background/Introduction Type 4a myocardial infarction (MI) occurs when myocardial injury is combined with either symptoms suggestive of myocardial ischaemia, new left bundle branch block, angiographic loss of patency of a major artery or imaging suggestive of new loss of myocardium. Myocardial injury is defined as a rise of >5 x 99th upper reference limit (URL) of 14 ng/l (i.e. >70 ng/l) for hi...

Dr. Januzzi and colleagues in a recent study (1) published in the Journal suggest replacement of creatine kinase-MB fraction (CKMB) with serum troponin testing for postoperative evaluation of the cardiac surgical patient. An important point to remember is the release pattern of these markers. Although the rise (CK-MB 4 to 8 h; CK-MB isoform 2 to 6 h; cardiac troponin I [cTnI] 4 to 6 h; cardiac ...

Sir, M of myocardial necrosis have gone through a long journey since 1950s.The cardiac biomarkers(CB) of past include total creatine kinase (CK) activity, aspartate aminotransferace activity (AST), lactate dehydrogenase (LDH) and LD1/LD2 ratio while the current CB are CK-MB, myoglobin, CKMB isoforms, cardiac troponin (cTn) I and T. The introduction of heart –type fatty–acid binding protein (H-F...

BACKGROUND & OBJECTIVE Recent meta-analysis reports have called for more randomized trials to evaluate the effectiveness of GIK solution in patients of cardiac surgery. So this study was conducted to evaluate the effectiveness of Glucose-insulin-potassium (GIK) solutions in non-diabetic patients undergoing coronary artery bypass grafting. METHODS A total number of one hundred and sixty (160) ...

OBJECTIVE Remote ischemic preconditioning (RIPC) induces transient episodes of ischemia by the occlusion of blood flow in non-target tissue, before a subsequent ischemia-reperfusion injury. When RIPC is applied before percutaneous coronary intervention (PCI), the kidneys may be protected against ischemia-reperfusion injury and subsequently contrast-induced acute kidney injury (CI-AKI). The aim ...

A 40-year-old fire fighter presented to an emergency room because of nausea, vomiting and muscle pains in the upper arms and thighs. He had been actively engaged in his profession until the time of admission and denied prior medical illnesses. He denied specific trauma or drug abuse. He was uncertain as to the colour of his urine. Physical examination disclosed a blood pressure of 125u80 mmHg. ...

man, with a clear medical history was admitted to the outpatients department complaining of a two hour retrosternal pain with accompanying sweating and nausea. The physical examination revealed normal body type, 65 bpm heart rate and 130/75 mmHg arterial pressure. Cardiac tones were discrete, rhythmic, without additional sounds and the lung auscultation was normal. Peripheral pulses in the uppe...

OBJECTIVE Xindening oral liquid (Xin) is a widely used traditional Chinese medicine for the treatment of chronic heart failure (CHF). However, the exact mechanisms related to its therapeutic effects against CHF remain unclear. In the present study, we investigate the effects of Xin on cardiac function in CHF rats and the possible mechanisms involved. METHODS Transverse aortic constriction (TA...