We have demonstrated suppression and elimination of self-pulsing in a watt-level, dual-clad, ytterbium-doped fiber laser. The addition of a long section of passive fiber in the laser cavity makes the gain recovery faster than the self-pulsation dynamics, allowing only stable cw lasing. This scheme provides a simple and practical method for eliminating self-pulsations in fiber lasers at all pump...

We report passive mode locking of a soliton erbium-doped double-clad fiber laser operating at the 322nd harmonic of the fundamental cavity frequency. Repetition rates up to 3 GHz have been obtained with pulses of 1 ps duration and 18 pJ of energy. The supermode suppression at the 322nd harmonic is better than 25 dB. In addition, the transition dynamics from a bunched state of pulses to stable h...

BACKGROUND Antibody-mediated rejection (AMR) after lung transplantation remains enigmatic, and there is no consensus on the characteristic clinical, immunologic and histologic features. METHODS We performed a retrospective, single-center cohort study and identified cases of acute AMR based on the presence of circulating donor-specific human leukocyte antigen (HLA) antibodies (DSA), histologic...

The demands of optical fiber-based biomedical applications can, in many cases, outstrip the capabilities of lens-based commercially available fiber optic rotary joints. In some circumstances, it is necessary to use very broad spectral bandwidths (near UV to short-wave IR) and specialized optical fibers, such as double-clad fiber, and have the capacity to accommodate high rotational velocities. ...

This article is not an overview of all facets of lung transplantation in cystic fibrosis (CF), but rather it is intended as a review of current allocation controversies, as well as of trends in diagnostics and management in lung transplant recipients and in patients with end-stage lung disease. Despite changes in donor and recipient selection, long-term survival in pediatric lung transplant has...

Lung transplantation (LTx) is a valid therapeutic option for selected patients with end-stage lung disease. HLA-E seems to play a major role in the immune response to different viral infections and to affect transplantation outcome, in Hematopoietic Stem Cell Transplantation, for example. Two nonsynonymous alleles, HLA-E(⁎)01:01 and HLA-E(⁎)01:03, have functional differences, involving relative...