Background/Aims: Standard triple therapy (STT; proton pump inhibitor [PPI]+clarithromycin+amoxicillin) used for Helicobacter pylori (H. pylori) eradication has shown low treatment success rates in recent years, which is most likely attributable to increased clarithromycin resistance. In this study, we compared of tailored (TT) using real-time polymerase chain reaction (RT-PCR) and empirical STT...

The susceptibilities to three antimicrobials of 195 Helicobacter pylori strains isolated from Mexican patients is reported; 80% of the strains were resistant to metronidazole, 24% were resistant to clarithromycin, and 18% presented a transient resistance to amoxicillin. Resistance to two or more antimicrobials increased significantly from 1995 to 1997.

BACKGROUND Antibiotic resistance is a major therapeutic problem in patients infected with Helicobacter pylori. H. pylori clarithromycin resistant mutants have been evolved during antibiotic therapy, this is mainly due to 23s rRNA point mutations. OBJECTIVES In the present study, we investigated anti-mutational features of four traditionally Iranian medicinal plants on three local isolated H. ...

According to a recent consensus statement concerning Helicobacter pylori infection in children (3), upper gastrointestinal endoscopy with biopsies is the preferred method for establishing an etiologic diagnosis of infection. The treatment recently recommended for children combines a gastric acid inhibitor, usually a proton pump inhibitor (PPI), with two antimicrobial agents, an antimicrobial ag...

BACKGROUND Helicobacter pylori eradication rates in Portugal are declining, due to increased resistance of this bacterium to antimicrobial agents, especially Clarithromycin. Quadruple Levofloxacin-containing regimens could be an option for first-line treatment, but its efficacy should be evaluated as fluoroquinolone resistance is rapidly increasing. Our aim was to compare the efficacy of Clarit...

OBJECTIVES/HYPOTHESIS To investigate the allelic prevalence of resistance to clarithromycin in the DNA of clinical isolates of Helicobacter pylori obtained from biopsy specimens of patients with chronic tonsillitis by Scorpion real-time polymerase chain reaction (PCR). STUDY DESIGN Pathologic specimens of patients with chronic tonsillitis were used for rapid urease test, and blocks of paraffi...

Helicobacter pylori causes peptic ulceration and gastric adenocarcinoma. The aims were to study the influence of dupA1 positivity upon interleukin-8 (IL-8) secretion from gastric mucosa and determine the prevalence of mutations responsible for clarithromycin and fluoroquinolone resistance. DNA was extracted from 74 biopsies and the virulence factors were studied. Levels of IL-8 in gastric mucos...

Plasmid-mediated kanamycin resistance was detected in a strain of Mycobacterium abscessus subsp. bolletii responsible for a nationwide epidemic of surgical infections in Brazil. The plasmid did not influence susceptibility to tobramycin, streptomycin, trimethoprim-sulfamethoxazole, clarithromycin, or ciprofloxacin. Plasmid-mediated drug resistance has not been described so far in mycobacteria.

The treatment of patients with Helicobacter pylori infection has many limitations, especially because antibiotic resistance. We aimed to investigate the prevalence and mechanism resistance metronidazole clarithromycin in H. isolates collected from gastrointestinal symptoms Qazvin, Iran. In this cross-sectional study, susceptibility testing was performed among 80 clinical strains isolated pylori...

Antibiotic resistance is considered the cause of unsuccessful eradication of Helicobactor pylori (H. pylori) infections. Awareness of regional resistance rates of H. pylori isolates can improve not only empiric antibiotic therapy but also lead to the development of second line treatment and rescue regimens. At present, the most common treatment is empiric eradication. Global regional regimen th...