Microphthalmia-associated transcription factor (MITF) acts as a master regulator of melanocyte development, function and survival by modulating various differentiation and cell-cycle progression genes. It has been demonstrated that MITF is an amplified oncogene in a fraction of human melanomas and that it also has an oncogenic role in human clear cell sarcoma. However, MITF also modulates the s...

Paediatric malignancies are relatively rare, with an annual frequency of 13-14 in 100 000 children up to 15 years, and account for less than 1% of all cancer in developed countries. Paediatric tumours are generally managed with a multi-modality treatment programme that includes surgery, chemotherapy, and external beam radiation therapy (EBRT). Treatment strategies directed towards the reduction...

Renal malignancies are common in children. While the majority of malignant renal masses are secondary to Wilms tumor, it can be challenging to distinguish from more aggressive renal masses. For suspicious renal lesions, it is crucial to ensure prompt diagnosis in order to select the appropriate surgical procedure and treatment. This review article will discuss the common differential diagnosis ...

desmoplastic small round cell tumor (dscrt) is a rare variant of sarcoma with a highly aggressive behavior. it usually affects abdominal cavity and has a male predominance. its correct diagnosis and treatment is sophisticated and requires an experienced multidisciplinary team. hereby we present a 25 yrold man from kerman province in 2013 with abdominal mass and ascites who underwent sonograghy ...