P ulmonary hypertension (PH) is a significant public health problem that may develop from abnormalities in the pulmonary vasculature, with left-sided heart failure (HF), high cardiac output states, or any combination of these. The commonest cause is HF (group 2 PH), 3 although many clini-cians continue to associate the term PH with the much smaller cohort of patients with isolated pulmonary vas...

The aim of this review is to inform clini-cians about the involvement of brain mechanisms in clinical hypertension and the applicability of recent findings to clinical practice. Clinicians, particularly cardiologists and nephrolo-gists, are now initiating clinical treatment of hypertension that targets the sympathetic nervous system using novel techniques, such as catheter-based renal denervati...

Would physicians override a do-not-resuscitate order when a cardiac arrest is iatrogenic? A sthma is a chronic, possibly life-threatening disease for which effective treatments are continually studied and made available. It is difficult to imagine a chest physician seeing a patient for some other ailment, and knowing that person also has asthma, offering nothing beyond the admonition, " You nee...

270 E vidence of a possible association between the use of selective serotonin reuptake inhibitors (SSRIs) and suicide in youth presents a vexing problem for clini-cians, youth and their families. Are these medications the most effective treatment for major depression in children, adolescents and young adults? Do SSRIs carry a greater risk for suicide than no treatment or alternative treatments...

Telehealthcare is an ideal vehicle for seeing evaluation in context. It is clear that evaluation techniques applied to other technologies – for example, the randomized controlled trial, or systematic review of randomized controlled trials – are difficult to apply in the face of very rapid technological advance and pressure on (and from) clinicians, service managers and policy makers, either to ...

objective: to evaluate the potential advantages of imipenem/cilastatin in control of fever in neutro-penic hsct recipients.patients and method: in this single-center study, 111 consecutive febrile episodes in 104 neutropenic hsct recipients with a mean age of 26 years were randomized to treatment either with imipenem/cilastatin 1 g, iv, q8h or cefepime (our standard regimen) 2 g, iv, q8h. if fe...

The reason why the NCI Workshop on Investigational Strat egies for Detection and Intervention in Early Lung Cancer was convened in Annapolis, Maryland, relates to the growing ex citement over reports of clinical trials suggesting benefit with the retinoid chemointervention approach in the upper airway, tamoxifen intervention with breast cancer, and the perceived potential of the growing body of...

We conducted an evidence-based review of literature regarding use of oral appliances (OAs) in the treatment of snoring and obstructive sleep apnea syndrome (OSA) from 1995 until the present. Our structured search revealed 141 articles for systematic scrutiny, of which 87 were suitable for inclusion in the evidence base, including 15 Level I to II randomized controlled trials and 5 of these tria...

Four women with metastatic breast cancer were treated with monoclo nal antibody 260K9-recombinant ricin A chain, a ricin A chain immuno conjugate (1C) which targets a M, 55,000 antigen expressed by human mammary carcinomas. Patients were treated by daily, 1-h i.v. injections for 6 to 8 consecutive days. Two patients were treated with 10 MR/kg daily and the two others were treated with 50 «ig/k...

cell-mediated immune (cmi) s t a t us and sub- popul at i ons o f pe r ipheral b l ood lymphocytes were investigated in one hundre d volunt a ry blood donors who were car r ier s of ag • he s a signi f i c ant decr e ase of t otal t-cells observed in hb ag carri e rs as compared t o normal controls. the percens t age o f active t-cells a nd b-lymphocytes did not d i f f e r signi f icant ly bet...