Ontario's clinical practice guidelines for neonatal abstinence syndrome (NAS) provide evidence-informed recommendations that address the needs of substance using pregnant women and newborns at risk of NAS. NAS is a complex and multifaceted issue that is escalating along with rapidly rising opioid use in Ontario. Reducing the incidence and impact of NAS requires immediate action in order to impr...

The National Asthma Education and Prevention Program (NAEPP) keeps clinical practice guidelines up to date by identifying selected topics on asthma that warrant intensive review based on the level of research activity reflected in the published literature or the level of concern in clinical practice. The NAEPP Expert Panel identified key questions about asthma management and used a systematic r...

BACKGROUND The ability to do online searches for health information has led to concerns that patients find the results confusing and that they often lead to expectations for treatments that have little supportive evidence. At the same time, the science of summarizing research evidence has advanced to the point where it is increasingly possible to quantify treatment tradeoffs and to describe the...

Clinical decisions must be made. Correct course of action may not be readily apparent. Multiple non-pharmacologic, pharmacologic, and device therapies are available. Reasonably valid methods exist to address knowledge base and evaluate medical evidence. Data beyond randomized clinical trials exist that enhance medical decision making. Uncertainties remain concerning approaches to treatment afte...

INTRODUCTION Despite widespread availability of clinical practice guidelines (CPGs), considerable gaps continue between the care that is recommended ('appropriate care') and the care provided. Problems with current CPGs are commonly cited as barriers to providing 'appropriate care'.Our study aims to develop and test an alternative method to keep CPGs accessible and up to date. This method aims ...

Undoubtedly, one of the most popular scientific activities within the European Society of Cardiology (ESC) is clinical practice guidelines. The guidelines are intended as an aid in our decisions with patients. However, there are clinical situations that are not included in the guidelines, or others that are supported by expert consensus in the absence of robust scientific evidence based on robu...

EASL–EORTC Clinical Practice Guidelines (CPG) on the management of hepatocellular carcinoma (HCC) define the use of surveillance, diagnosis, and therapeutic strategies recommended for patients with this type of cancer. This is the first European joint effort by the European Association for the Study of the Liver (EASL) and the European Organization for Research and Treatment of Cancer (EORTC) t...