نتایج جستجو برای: clinically isolated syndrome
تعداد نتایج: 1033495 فیلتر نتایج به سال:
Introduction Many previous studies have observed atrophy and abnormal water diffusivity within the corpus callosum (CC) of multiple sclerosis (MS) patients [1, 2]. However, few studies have addressed the question whether such abnormalities exist in the earlier stages of MS, especially in clinically isolated syndrome (CIS). In this study, we aimed to investigate CC abnormalities in CIS patients ...
BACKGROUND Axonal and neuronal damage are widely accepted as key events in the disease course of multiple sclerosis. However, it has been unclear to date at which stage in disease evolution neurodegeneration begins and whether neuronal damage can occur even in the absence of acute inflammatory attacks. OBJECTIVE To characterize inner retinal layer changes in patients with clinically isolated ...
OBJECTIVE To aid in the timely diagnosis of patients who present with clinically isolated syndrome (CIS). PATIENTS AND METHODS We studied 25 patients (18 women, 7 men), originally presented in our clinic with a CIS suggestive of multiple sclerosis (MS). All patients underwent the full investigation procedure including routine tests, serology, cerebrospinal fluid (CSF) examinations, evoked pot...
OBJECTIVE To determine whether childhood obesity is a risk factor for developing pediatric multiple sclerosis (MS) or clinically isolated syndrome (CIS). METHODS Cases were identified through the Kaiser Permanente Southern California (KPSC) pediatric acquired demyelinating diseases cohort between 2004 and 2010. For cases, body mass index (BMI) was obtained prior to symptom onset, for the unde...
BACKGROUND Patients with clinically isolated syndrome (CIS) demonstrate brain hemodynamic changes and also suffer from difficulties in processing speed, memory, and executive functions. OBJECTIVE To explore whether brain hemodynamic disturbances in CIS patients correlate with executive functions. METHODS Thirty CIS patients and forty-three healthy subjects, matched for age, gender, educatio...
PURPOSE To assess if higher-resolution magnetic resonance elastography (MRE) is a technique that can measure the in vivo mechanical properties of brain tissue and is sensitive to early signatures of brain tissue degradation in patients with clinically isolated syndrome (CIS). MATERIALS AND METHODS Seventeen patients with CIS and 33 controls were investigated by MRE with a 3T MRI scanner. Full...
OBJECTIVE To test efficacy and safety of atorvastatin in subjects with clinically isolated syndrome (CIS). METHODS Subjects with CIS were enrolled in a phase II, double-blind, placebo-controlled, 14-center randomized trial testing 80 mg atorvastatin on clinical and brain MRI activity. Brain MRIs were performed quarterly. The primary endpoint (PEP) was development of ≥ 3 new T2 lesions, or one...
BACKGROUND Compared to 1.5 T, 3 T magnetic resonance imaging (MRI) increases signal-to-noise ratio leading to improved image quality. However, its clinical relevance in clinically isolated syndrome suggestive of multiple sclerosis remains uncertain. OBJECTIVES The purpose of this study was to investigate how 3 T MRI affects the agreement between raters on lesion detection and diagnosis. MET...
BACKGROUND Oligoclonal bands (OCB) are the most widely used CSF test to support the diagnosis of MS and to predict conversion of clinically isolated syndrome (CIS) to multiple sclerosis (MS). Since OCB tests are based on non-quantitative and difficult to standardise techniques, measurement of immunoglobulin kappa free light chains (KFLC) may represent an easier to use quantitative test. METHO...
Extracellular vesicles (EVs), nanoparticles originated from different cell types, seem to be implicated in several cellular activities. In the Central Nervous System (CNS), glia and neurons secrete EVs and recent studies have demonstrated that the intercellular communication mediated by EVs has versatile functional impact in the cerebral homeostasis. This essential role may be due to their prot...
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