BACKGROUND Toxic epidermal necrolysis (TEN) is a rare systemic allergic drug eruption with high patient mortality. Currently, no established treatments have been shown to be effective for TEN beyond supportive care. Prior studies of systemic corticosteroids have yielded conflicting data, with some showing a possible benefit and others reporting in increased mortality. However, topical steroids ...

A 69-year-old woman with a history of colon carcinoma, cirrhosis of the liver secondary to hepatitis C, and erosive oral lichen planus presented to the dermatology clinic for therapeutic options regarding a growing ulceration on her lower lip. In the past year, the ulceration had enlarged and she had begun to develop new, painful, shallow ulcerations in the oral mucosa. In addition, she complai...

The work aimed at studying a new mucoadhesive prolonged release tablet containing 24 μg clobetasol-17 propionate (CP) suitable for the management of oral lichen planus. Low swellable dosage forms were designed by combining a mucoadhesive polymer, i.e. poly(sodium methacrylate, methylmethacrylate), with hydroxypropylmethylcellulose and MgCl₂. This formulation was selected to modify the tablet er...

An otherwise healthy 53-year-old woman was admitted to our Dermatologic Clinic for evaluation of two erythematous plaques on the front and back of both her thighs, which had developed over the previous ten months (Figure 1A). These plaques showed vegetative or hypertrophic elements, and were occasionally pruritic. The rest of her skin and mucosal surfaces were normal, the patient being in good ...

In psoriasis, T-cell infiltration and epidermal hyperproliferation are key phenomena which are closely related. Our aim was to investigate the dynamics among T-cell subsets in relation to epidermal proliferation and clinical severity in psoriasis during treatment with an ultra-potent corticosteroid. Seven psoriasis patients were treated twice daily for 14 days with clobetasol-17 propionate oint...

A 65-year-old man had an 8-year history of erosive, pustular, and atrophic lesions on his alopecic scalp (Figure1). The lesions developed since 1992, after treatment of actinic keratoses by topical fluorouracil and local trauma. Histologic examination of a skin biopsy specimen revealed an ulcerated atrophic epidermis with parakeratosis; a chronic inflammatory dermal infiltrate composed of lymph...

I n the 2004 Burden of Skin Disease study conducted by the American Academy of Dermatology Association and the Society for Investigative Dermatology, approximately 90.6 million Americans were reported to be affected by psoriasis, atopic dermatitis, and allergic contact dermatitis. Importantly, the leading therapeutic modality for these dermatitides isunquestionably topical corticosteroids. Alth...

Haemodialysis is the most frequent form of renal replacement therapy (RRT) in patients with end-stage renal disorder (ESRD). Patients with ESRD frequently develop skin problems, mainly xerosis, pruritus and hyperpigmentation, as well as bullous diseases, mainly porphyria or pseudoporphyria and, in some cases, bullous pemphigoid (BP). BP is the most common autoimmune sub-epidermal blistering dis...

INTRODUCTION Clinical studies indicate that contact allergy to glucocorticosteroids (GCS) is not rare and has been increasingly reported over the past decade. Among the risk factors for developing contact hypersensitivity to topical corticosteroids, chronic inflammatory skin diseases and polyvalent contact allergy seem to be most important. AIM To present the structure of contact allergy in t...

Drug reaction with eosinophilia and systemic symptoms (DRESS) is a severe cutaneous adverse involving multiorgan failure, complex interaction of various drugs, human herpesvirus reactivation immune abnormalities suggested as the aetiology. We herein present case 70-year-old man one-week history fever, facial oedema, erythematous macules purpura on his trunk extremities. He had anti-TIF1γ antibo...