نتایج جستجو برای: clock centers

تعداد نتایج: 158899  

Journal: :Nature Reviews Molecular Cell Biology 2011

Journal: :PLOS Biology 2015

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2006
Martha Hotz Vitaterna Caroline H Ko Anne-Marie Chang Ethan D Buhr Ethan M Fruechte Andrew Schook Marina P Antoch Fred W Turek Joseph S Takahashi

The mouse Clock gene encodes a basic helix-loop-helix-PAS transcription factor, CLOCK, that acts in concert with BMAL1 to form the positive elements of the circadian clock mechanism in mammals. The original Clock mutant allele is a dominant negative (antimorphic) mutation that deletes exon 19 and causes an internal deletion of 51 aa in the C-terminal activation domain of the CLOCK protein. Here...

Journal: :Current Biology 2007
Jason P. DeBruyne David R. Weaver Steven M. Reppert

In mammals, the circadian system is hierarchical — a brain pacemaker located within the suprachiasmatic nucleus (SCN) is responsible for regulating locomotor activity rhythms and for synchronizing peripheral oscillators [1,2]. Recent genetic evidence in mice indicates that the bHLH transcription factors CLOCK and NPAS2 have partially redundant functions within the SCN [3,4]. To further examine ...

Journal: :Cell 2003
Jie Zhao Valerie L Kilman Kevin P Keegan Ying Peng Patrick Emery Michael Rosbash Ravi Allada

Circadian rhythms of behavior, physiology, and gene expression are present in diverse tissues and organisms. The function of the transcriptional activator, Clock, is necessary in both Drosophila and mammals for the expression of many core clock components. We demonstrate in Drosophila that Clock misexpression in nai;ve brain regions induces circadian gene expression. This includes major compone...

1999
Ian Brynjolfson Zeljko Zilic

Clock management circuits are relatively new FPGA architectural blocks that are critical to solving clock distribution problems associated with high-speed, high-density designs. We outline the use of three FPGA clock managers in a variety of applications, and consider their application to low-power systems which adjust clock rates based on the amount of computation needed. Dynamic clock managem...

Journal: :Nature Reviews Molecular Cell Biology 2009

Journal: :Proceedings of the National Academy of Sciences 1930

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