نتایج جستجو برای: clozapine
تعداد نتایج: 3536 فیلتر نتایج به سال:
OBJECTIVE To analyze cases of clozapine-induced myocarditis for clinical and diagnostic trends. METHOD A case definition was developed by a multidisciplinary group using reports of myocarditis with clozapine submitted to the Australian Therapeutic Goods Administration. The definition uses for diagnosis either histology or the combination of new signs of cardiac dysfunction combined with a car...
Schizophrenia is a chronic psychiatric disorder with complex genetic and environmental origins. While many antipsychotics have been demonstrated as effective in the treatment of schizophrenia, a substantial number of schizophrenia patients are partially or fully unresponsive to the treatment. Clozapine is the most effective antipsychotic drug for treatment-resistant schizophrenia; however, cloz...
The introduction of antipsychotic medication in the 1950s forever changed the outlook on the treatment of schizophrenia, although there is still a large proportion of patients who do not reach functional recovery. At least 30% of patients do not respond to clozapine, the tricyclic dibenzodiazepine with complex pharmacological actions, which was proven to be more effective than any other antipsy...
BACKGROUND Despite the demonstrated efficacy of clozapine in severely refractory schizophrenia, questions remain regarding its efficacy for primary negative symptoms, comparison with a moderate dose of a first-generation antipsychotic, and adverse effects during a longer-term trial. This study examined its efficacy in partially responsive, community-based patients, compared clozapine with moder...
Background: Therapeutic options for patients with treatment-resistant schizophrenia are limited. In such cases, a combination of atypical antipsychotic drugs is an often used strategy. We tested the hypothesis that the combination of amisulpride and clozapine would lead to long-term improvement in this patient group. Objective: 15 patients with treatment-resistant schizophrenia participated in ...
Clozapine and olanzapine are two atypical antipsychotics that bind to a broad range of receptors in vitro. Our group previously reported on the binding of clozapine and olanzapine to muscarinic receptors in vivo. Based on these data, a direct comparison of the muscarinic receptor availability in vivo under treatment with these atypical antipsychotics was performed. [123I]IQNB SPECT scans were o...
Clozapine is the treatment of choice for refractory schizophrenia. However, a retrospective analysis indicated that death was a common cause of ceasing clozapine treatment. In another study that investigated the reasons for discontinuing clozapine, pneumonia was the primary cause of death in about 24% of patients. Therefore, the relation between the risk of pneumonia and clozapine has raised cl...
Clozapine (an atypical antipsychotic drug) is indicated in treatment-refractory schizophrenia. Antipsychotics have been reported to have cardiotoxic effects in humans.The zebra fish (Danio rerio) is a tropical cyprinid used in toxicological research. In the present study, the toxicity of clozapine was evaluated in zebra fish embryos with the aid of the fish embryo toxicity test (FET). The endpo...
Clozapine, a tricyclic dibenzodiazepine, is an atypical antipsychotic with dopaminergic, muscarinic, histaminic and serotonergic activity that has been used in the treatment of schizophrenia [1]. Although prescribers commonly recognize the hematologic adverse effect agranulocytosis its cardiac side effects, such as myocarditits, are less often considered [2]. A retrospective analysis of an Aust...
Recent studies have indicated that impaired neural circuitry in the prefrontal cortex is a prominent feature of the neuropathology of schizophrenia. Clozapine is one of the most effective antipsychotic drugs used for this debilitating disease. Despite its effectiveness, the mechanism by which clozapine acts on prefrontal cortical circuitry remains poorly understood. In this study, in vitro mult...
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