Abstract BACKGROUND Breast cancer is the most common in world and second to metastasize central nervous system (CNS). CNS-metastases are type of brain tumor have a rising incidence. They associated with neurologic morbidity mortality remain major clinical challenge. Survival withCNS-metastases short median survival order months. The incidence 5.1% breast however true prevalence not known; at au...

The rational design of a novel class trivalent thrombin inhibitors is described through the hybridization natural sulfopeptides produced by blood feeding organisms. hybrid were rapidly assembled using peptide ligation chemistry and shown to exhibit femtomolar inhibition constants against thrombin. A lead inhibitor also showed potent generation platelet aggregation in vitro, as well antithrombot...

Interstitial fibrin deposition is a common histologic feature of tubulointerstitial diseases, which suggests that the coagulation system is activated. Thrombin, generated during the activation of the coagulation cascade, is a powerful activating factor for different cell types. Although proximal tubular cells are potential targets for this coagulation factor, no information is available on the ...

While the central nervous system (CNS) was once thought to be immune privileged, more recent data support that certain areas of the healthy CNS are routinely patrolled by immune cells. Further, antigen drainage is another means by which the adaptive arm of the immune system can gain information about the health of the CNS. Altogether these ensure that the CNS is not beyond the scope of immune p...

Guillain-Barré syndrome (GBS) and its variants are parainfectious (2/3 cases) neurological illness involving the lower motor neuron but they can also involve central nervous system (CNS). Bickerstaff brainstem encephalitis (BBE) Miller Fisher (MFS) two of GBS with CNS involvement. The present case series highlights variable presentation laboratory findings in BBE MFS, which may help clinicians ...

I f you cut yourself, your hemostatic system will recruit circulating platelets and plasma fibrinogenyfibrin to staunch the loss of blood. These two arms of hemostasis combine to produce the hemostatic plug, comprised of aggregated platelets and deposited fibrin. ‘‘Plug’’ formation is regulated in terms of time, place, and extent so as to minimize bleeding from injured arteriesyveins, while avo...

OBJECTIVE To determine the influence of thrombin, which is generated intraperitoneally during peritoneal dialysis, on the synthesis of fibrinolytic system components in human peritoneal mesothelial cells (HMC). METHODS Confluently grown HMC, isolated from the omental tissue, were used in the experiments. Conditioned media were obtained by incubating cells with serum-free M199 containing the a...

Microglia is a type of glial cell located throughout the central nervous system (CNS), which is sensitive to CNS injury and disease. Responsibility of microglia as the resident macrophage cells for injuries suggests that these cells have the potential to act as diagnostic markers of disease beginning or progression. Function of Microglia is strongly synchronized by the microenvironment of brain...

Both the safety and effectiveness of intrathecal tigecycline (TGC) for treatment infections central nervous system (CNS) are discussed using clinical findings from a study recent patient who came to our attention, along with literature review. Although penetration into CNS is low (approximately 11%), intraventricular TGC could help treat patients severe post- neurosurgical infections. The use m...