نتایج جستجو برای: coagulability
تعداد نتایج: 307 فیلتر نتایج به سال:
M ORTALITV fromn coronary heart disease is believed to be almost unknown among rural South African Bantu ; even among urban dwellers, deaths from the disease as proved at necropsy are extremely few.”2 Confirmation of this belief is being obtained from a collaborative clinical and biochemical study now in progress on Johannesburg Bantu pensioners over sixty years old (some approaching 100 years ...
Factor VII levels have been measured in 100 patients with liver disease following parenteral vitamin K1 therapy. There was good agreement between specific factor VII measurements and the one-stage prothrombin time apart from six patients with compensated cirrhosis in whom the prothrombin time was prolonged despite the presence of normal factor VII levels. A mean activity of 58% was found in pat...
This study aimed to study the clinical significance of the thrombelastography (TEG) and coagulation parameters in septic patients. 92 septic patients were divided into three groups: sepsis group, sever sepsis group, and septic shock group. At the same time, they were divided into survival group and death group according to their outcomes. Results showed that the difference in days of hospitaliz...
OBJECTIVE To investigate the relation between intracardiac thrombus and blood coagulability in patients with mitral stenosis. DESIGN Prospective study. Cross sectional echocardiography and plasma concentrations of the D-dimer fragment of fibrin were used concurrently to detect intracardiac thrombus in patients with mitral stenosis. SETTING Department of Medicine, National Cardiovascular Cen...
BACKGROUND Only a few mutations associated with qualitative protein S deficiency have already been described. Sensitivity and specificity for type II PROS1 mutations of commercially available reagents for measuring Protein S (PS) activity are not well established. Whether these mutations are significant risk factors for thrombosis remains an unresolved question. METHODS In order to address th...
Proof-of-concept Studies for siRNA-mediated Gene Silencing for Coagulation Factors in Rat and Rabbit
The present study aimed at establishing feasibility of delivering short interfering RNA (siRNA) to target the coagulation cascade in rat and rabbit, two commonly used species for studying thrombosis and hemostasis. siRNAs that produced over 90% mRNA knockdown of rat plasma prekallikrein and rabbit Factor X (FX) were identified from in vitro screens. An ionizable amino lipid based lipid nanopart...
The concentration of particles in the ambient air is associated with deaths from cardiovascular disease, and determining the biologic mechanisms involved has been identified as a high-priority research need. Hypotheses have focused on the possibility of direct cardiac effects, or indirect effects related to inflammatory responses, including increased blood viscosity or increased blood coagulabi...
A 69-year-old obese man (body mass index, 30.3) presented with acute left abdominal pain after severe coughing. He had no history of direct abdominal trauma. He was not receiving anticoagulant therapy. A physical examination showed a smooth painful mass on his left abdominal wall. The laboratory findings were a platelet count of 196,000/ mm and a normal range of coagulability. Ultrasonography r...
BACKGROUND Patients on warfarin therapy undergo invasive and expensive checks for the coagulability of their blood. No information on coagulation levels is currently available between two controls. METHODOLOGY A method was developed to determine warfarin in oral fluid by HPLC and fluorimetric detection. The chromatographic separation was performed at room temperature on a C-18 reversed-phase ...
It is today generally accepted, that the intestinal bacterial flora is deeply involved in the pathogenesis of human inflammatory bowel diseases (IBDs), although the exact presence of unwanted or lack of specific crucial bacteria are not yet known. Westerners lack to large extent important immunomodulatory and fibre-fermenting lactic acid bacteria (LAB), bacteria which are present in all with a ...
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