a “cocktail”of several probe drugs is often used to evaluate metabolic activity of multiple cytochrome p450 enzymes in one session. some interactions among probe drugs can appear and may impact the rate of biotransformation of other ones. our presented work was to aim on the influence of bupropion on rat cytochrome p450-mediated metabolism of tolbutamide. the biotransformation rates of tolbutam...

OBJECTIVE To examine the impact of VAC therapy on mortality of patients with sternal wound infections after cardiothoracic surgery. SUMMARY BACKGROUND DATA Controversial results regarding mortality of patients with sternal wound infections were published. METHODS We performed a systematic search in PubMed and Scopus. Mortality was the primary outcome of the meta-analysis. Recurrences, compl...

BACKGROUND The aim of this study was to investigate the effects of negative pressure therapy in the regeneration of the rabbit sciatic nerve using vacuum assisted closure (VAC). MATERIAL AND METHODS Thirty male New Zealand white rabbits underwent surgical injury of the sciatic nerve, followed by negative pressure therapy using vacuum assisted closure (VAC), in three treatment groups: Group A: 0...

UNLABELLED Background. Vacuum-assisted closure (V.A.C.® Therapy, KCI, San Antonio, TX) has been widely used to increase the healing rate of a variety of wounds. It has been hypothesized that one of the actions of VAC is to increase perfusion and subsequent oxygenation of tissue. The aim of the present study was to investigate the effect of VAC therapy on transcutaneous oximetry measurements (T...

Transvenous electrodes were placed in the right atrium and ventricle of 50 patients with heart disease and arrhythmias. The ventricles were paced at several rates, each in excess of the sino-atrial rate. An atrial electrogram and surface electrocardiogram were recorded simultaneously in each patient; utilizing strict criteria, the incidence with which 1:1 ventriculo-atrial conduction (VAC) coul...

BACKGROUND Abdominal compartment syndrome (ACS) is a clinical syndrome characterized by progressive intraabdominal organ dysfunction resulting from an acute increase in intra-abdominal pressure (IAP). In the absence of prompt treatment, ACS can lead to lethal organ failure. Treatment of ACS is achieved by immediate decompression of the abdominal cavity. As to how and when decompression laparoto...

Here we propose an easy to build up and apply glass slide preparation system for single DNA molecules stretching. It is based on fast and simple coating of a solid glass with a cocktail of acrylic monomers that are easily polymerized via ultraviolet illumination. The acrylated slides are used to successfully stretch DNA molecules in a broader pH range compared to that of the commonly used amino...

Epidemiological and clinical studies provide compelling support for a causal relationship between Helicobacter pylori infection and endothelial dysfunction, leading to vascular diseases. However, clear biochemical evidence for this association is limited. In the present study, we have conducted a comprehensive investigation of endothelial injury in bovine aortic endothelial cells (BAECs) induce...