Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in the Western world. Oxidative stress appears to play a pivotal role in atherosclerosis. Coenzyme Q10 (CoQ10), one of the most important antioxidants, is synthesized de novo by every cell in the body. Its biosynthesis decreases with age and its deficit in tissues is associated with degenerative changes of aging, thus ...

Maintenance of mitochondrial activity and antioxidant features of coenzyme Q10 (CoQ10) could be an effective background for treatment of acute myocardial ischemia. Dietary uptake of CoQ10 is limited to only a few percent. In urgent cases, parenteral administration of CoQ10 could provide fast increase of its plasma and myocardial levels. The aim was to evaluate whether a single intravenous (i.v....

For a number of years, coenzyme Q (CoQ10 in humans) was known for its key role in mitochondrial bioenergetics; later studies demonstrated its presence in other subcellular fractions and in plasma, and extensively investigated its antioxidant role. These two functions constitute the basis on which research supporting the clinical use of CoQ10 is founded. Also at the inner mitochondrial membrane ...

coenzyme q10, a lipid soluble benzoquinone, has excellent antioxidant and membrane stabilizing properties in the cardiac tissue. the present study investigated the effects of coenzyme q10 on in vitro ldl oxidation quantitavely. the formation of conjugated dienes, malondialdehyde (mda) and electrophoretic mobility were monitored as markers of the oxidation of ldl, respectively. coenzyme q₁₀ show...

Energy generation and utilization have been the focal points of many research groups trying to elucidate the pathways, deficiencies, and enhancement of the energy-generation centers of the cell, the mitochondria (2). In mitochondrial function, coenzyme Q10 (CoQ10; ubiquinone) has a unique function in oxidative phosphorylation and the generation of adenosine triphosphate (3). The myocardial and ...

BACKGROUND Acute liver damage may be followed by biochemical, behavioral, and pathological alterations, which can result in serious complications and even death. OBJECTIVES In this experimental study we determined whether coenzyme Q10 (CoQ10), a common supplementary medicine known to have protective, antioxidative, and anti-inflammatory effects in cells, has any protective effect against thio...

Natural lipophilic bioactives that possess human health benefits, such as coenzyme Q10 (CoQ10) and R-α-lipoic acid (RALA), often have undesirable characteristics that limit their use as nutraceuticals and cosmeceuticals. These bioactives are usually unstable against oxygen, ultraviolet light, low pH and heat. Furthermore, their watersolubility is low because of their hydrophobic nature or insta...

Intensive physical exercise may cause muscular injury and increase oxidative stress. The purpose of this study was to examine the effect of an antioxidant, coenzyme Q10 (CoQ10), on muscular injury and oxidative stress during exercise training. Eighteen male students, all elite Japanese kendo athletes, were randomly assigned to either a CoQ10 group (n 10) or a placebo group (n 8) in a double-bli...

CoenzymeQ10 (CoQ10) is used as a food supplement and as an ethical drug because of its antioxidant functions and key role in mitochondrial bioenergetics. In this study, the effects of CoQ10 on blood biochemistry and malondialdehyde (MDA) levels in rats were investigated. Ten male Wistar rats ages ranging between 7 and 8 weeks were used. All animals were kept under the same condition and were gi...

objective(s) the present study aimed to investigate the effects of a fat soluble antioxidant, coenzyme q10 (coq10) and folic acid on learning and memory in the rats with intracerebroventricular injection of streptozotocin (icv-stz), an animal model of sporadic type of alzheimer's disease. materials and methods the lesion groups were injected bilaterally with icv-stz (1.5 mg/kg b.wt., in no...