Introduction Familial Mediterranean Fever (FMF), is an autosomal recessive disease associated with mutations in the MEFV gene, affecting mostly Mediterranean populations (Armenians, Arabs, Jewsand, Turks). It is characterized by self-limited recurrent attacks of fever and serositis [1]. Since 1972, colchicine is the standard treatment in FMF patients and majority of the patients achieve complet...

M e t h o d s Design: Randomized controlled trial (COlchicine for REcurrent pericarditis [CORE] trial). Allocation: {Concealed}†.* Blinding: Blinded {data collectors, outcome assessors, monitoring committee, and data analysts}†.* Follow-up period: Mean 20 months (range 8 to 44 mo). Setting: A hospital in Torino, Italy. Patients: 84 patients ≥ 18 years of age (mean age 54 y, 65% women) who had a...

Background Acute postoperative pain is induced by most incisional surgeries and usually resolves with wound repair. However, many patients experience moderate to severe pain despite receiving currently available postoperative pain relief. Accumulating evidence suggests that inflammatory cells, neutrophils, and macrophages infiltrating the wound site contribute to the acute inflammation, pain, a...

introduction: according to previous studies, colchicine causes neuronal destruction and learning depression. in this project, effects of colchicine injection into the ca1 and interaction between colchicine and nitric oxide (no) in this area on the expression of drug-seeking behavior were investigated. methods: wistar rats (250-300 g) were bilaterally cannulated at the ca1 area. colchicine (2-8 ...

Pericardial effusion represents a common postoperative complication in cardiac surgery. Nonetheless, it can be resistant to conventional therapy leading to prolonged in-hospital stay and worsening of clinical conditions. Recent literature shows that colchicine therapy should be useful in the treatment of recurrent post surgical pericardial effusion. Hereby we report the case of a patient with p...

Colchicine is a unique anti-inflammatory drug with respect to its limited clinical usefulness and its mode of action. Colchicine is mainly indicated for the treatment and prophylaxis of gout and familial Mediterranean fever. Its mode of action includes modulation of chemokine and prostanoid production and inhibition of neutrophil and endothelial cell adhesion molecules by which it interferes wi...

We applaud Cronstein and Terkeltaub [1] on their comprehensive review of the inflammatory process of gout and its treatment. Although they allude to the fact that colchicine probably has the smallest therapeutic window of any drug used to treat acute gouty arthritis, they have suggested " In treating acute gouty arthritis colchicine is typically administered as an oral 0.6 mg dose, followed by ...

Familial Mediterranean fever (FMF), an inherited autosomal recessive disorder, is characterized by sporadic, paroxysmal attacks of fever and serosal inflammation, lasting 1-3 days. Patients may develop renal amyloidosis, arthritis, serositis, and skin and oral lesions. Diagnosis is based on clinical features, response to treatment with colchicine, and genetic analysis. Colchicine prevents attac...

BACKGROUND Familial Mediterranean fever (FMF) has episodic or subclinical inflammation that may lead to a decrease in bone mineral density (BMD). The objective of this study was to assess BMD in Egyptian children with FMF on genetic basis. METHODS A cross sectional study included 45 FMF patients and 25 control children of both sexes in the age range between 3-16 years old. The patients were r...

INTRODUCTION In 5%-10% of patients with familial Mediterranean fever (FMF), colchicine is not effective in preventing inflammatory attacks. Another 5%-10% of patients are intolerant to effective doses of colchicine and experience serious side effects. Treatment with anti-interleukin-1 (IL-1) drugs may be an alternative for these patients, although it is not reimbursed for this indication in man...