AIM To explore the relationship between colonic secretory function and colonic motility. METHODS Using a rat model chronically implanted with intracerebroventricular (ICV) and cecal catheters, we validated the correlation between colonic secretion and colonic motor functions, as well as the role of ICV injection volume. RESULTS Compared to saline controls (5 μL/rat), ICV acyl ghrelin at 1 n...

Pectin is a polysaccharide of natural origin, which has been widely exploited in the food and pharmaceutical industry due to its biodegradable biocompatible nature. It commonly used as an efficient texturizer stabilizer different products high stability also excipient various drug formulations valuable characteristics. The utilization pectin carrier for achieving controlled release dosage forms...

BACKGROUND Chronic constipation is one of the most common chronic disease in children. Most of cases are functional, however some has problem of organic myopathic or neuropathic colon. Colonic transit study with oro-anal transit markers is the basic diagnostic tool for colonic dysmotility in clinical practice, colonic manometry is the recommended investigation in the next step. Nevertheless, th...

Ilias Kouerinis, Kipselis 17, 11257 Athens, Greece, e-mail: [email protected] Conversely, several degrees of colonic lesions following pancreatic abscess formation have been described: a) localized paralytic ileus of the transverse colon b) Intramural involvement of the colon in a localized area c) colonic stricture simulating colonic carcinoma d) colonic bleeding e) colonic fistula. The i...

Background/Aims After exclusion of structural diseases, chronic constipation may be associated with normal or slow transit or rectal evacuation disorders. We evaluated: (1) clinical features and anorectal function, (2) difference of regional colonic transit according to the presence or absence of evacuation disorders, and (3) association of colonic transit with gender in patients with objective...

delivery of exogenous materials such as nucleic acids, peptides, proteins, and drugs into cells is an important strategy in modern cellular and molecular biology. recently, the development of gene carriers for efficient gene transfer into cells has attracted a great attention. furthermore, lack of effective drug delivery is one of the major problems of cancer chemotherapy. many physical methods...