temperature restrictions on aqueous effluents dictate that streams with a temperature higher than the permitted level needed to pass through cooling systems to reduce the effluent temperature before discharge. in this study, by considering the grouping design rules based on pinch technology, an optimum design for a distributed effluent cooling system, has been developed. a counter-flow wet cool...

avicenna (980 – 1037 ad) known as the prince of physicians in the west was one of the most prominent persian thinkers, philosophers, and physicians. owing to his interests in cardiology, he authored considerable works on different aspects of cardiology. “resaley-e-ragshenasi” (book on pulsology) and”kitab al-adviyt- ol-qalbiye” (the book on drugs for cardiovascular diseases) are avicenna’s grea...

background: prostate cancer after lung cancer is the second cause of cancer-associated death in men. in recent years, targeted therapy of cancer has attracted researchers attention. the targeted therapy lead to decrease in side effects of drugs. studies have indicated that targeting peptides for cancer cells represent valuable tools for diagnostic and therapeutic. recently, phage display peptid...

Overexpression of human progastrin increases colonic mucosal proliferation and colorectal cancer progression in mice. The G-protein coupled receptor 56 (GPR56) is known to regulate cell adhesion, migration, proliferation and stem cell biology, but its expression in the gut has not been studied. We hypothesized that the promotion of colorectal cancer by progastrin may be mediated in part through...

Tumor targeting of five radioiodinated murine monoclonal antibodies (MAbs) directed against human colorectal cancer were studied in nude mice bearing the GW-39 human colonic tumor xenograft. All of the MAbs are of the IgG1 isotype. Two of the MAbs (NP-4 and MN-14) are directed against a Class III carcinoembryonic antigen-specific epitope, but they differ 10-fold in their affinity. The other thr...

The increase in incidence of colonic diverticular bleeding is relative to an age-related rise in the incidence of colonic diverticulosis and use of antithrombotic medication. However, risk factors related to the onset, recurrence, and prophylaxis have not been established. Therefore, we aimed to determine risk factors for the onset and recurrence of colonic diverticular bleeding.An age- and sex...

Unitary discharges were recorded from the inferior mesenteric ganglion of decerebrate dogs. Eighty-one units were identified as sympathetic postganglionic neurons innervating the colon and rectum by collision test performed by stimulation of the lumbar colonic nerve. Discharges of four units were enhanced simultaneously with an increased outflow of the renal nerve by pinching a toe. Thus, those...

Abstract Background: Acute Graft versus host disease (aGVHD) is one of the most common complication allogeneic hematopoietic stem cell transplant. We have previously shown that infused immune-modifying particles (IMPs) can reduce clinical symptoms and improve survival in inflammatory conditions. IMPs are taken up by monocytes (θIM) via macrophage receptor with collagenous structure (MARCO) then...

Mycotoxin intoxication is in general an acknowledged and tackled issue animals. However, several parts of the world, mycotoxicoses humans still remain a relevant issue. The efficacy two mycotoxin detoxifying animal feed additives, aflatoxin bentonite clay binder fumonisin esterase, was investigated human child gut model, i.e. vitro Simulator Human Intestinal Microbial Ecosystem (SHIME®). Additi...