Colorectal cancer (CRC) is the third most commonly diagnosed malignancy in the world. Screening for CRC or its precursor lesions (adenomas) by endoscopy with polypectomy has been shown to reduce CRC incidence and mortality. More vigilant screening and surveillance by colonoscopy is recommended for certain high-risk populations, for example patients with a positive family history of CRC and thos...

Colorectal cancer (CRC) remains one of the leading causes of cancer related deaths in the United States. Currently, there are limited therapeutic options for patients suffering from CRC, none of which focus on the cell signaling mechanisms controlled by the popular kinase family, cyclin dependent kinases (CDKs). Here we evaluate a Pfizer developed compound, CP668863, that inhibits cyclin-depend...

Hepatic metastasis is the most critical prognostic factor for colorectal cancer (CRC), and early detection of CRC liver metastasis can significantly improve cancer patient outcomes. In this study, we examined the levels of CPA4 in CRC samples, and assessed the potential of serum CPA4 as a biomarker for predicting CRC liver metastasis. CPA4 positivity was observed in 68.4% (130/190) colorectal c...

Background The prevalence of prescribed drugs in survivors colorectal cancer (CRC) was evaluated. Methods Data from the Cancer Registry Norway were linked to Norwegian Prescription Database for a study population 3.52 million individuals. Prevalence ratios (PRs) with 95% confidence intervals (CIs) CRC-survivors compared cancer-free population, estimated by log-binomial regression, adjusting age...

Considering the high prevalence of colorectal cancer (CRC) and relatively high mortality there is strong interest in identification of clinically relevant biomarkers. Telomere shortening is supposed to contribute to genomic instability and crucially involved in process of carcinogenesis. Peripheral blood leukocyte (PBL) telomere length was previously investigated in several studies as potential...

Background: Colorectal cancer (CRC) is among the most common and preventable cancers, incidence risk factors of which are different in various populations. Objectives: The present study aims at assessing rate, factors, symptoms CRC populations aged 50 to 70 years old covered by health centers Arak, as well evaluating participation rate screening program. Methods: cross-sectional was conducted f...

impact of the Dutch colorectal cancer screening program on cancer incidence and mortality – model-based exploration of the serrated pathway 3 Chapter 3 – Long-term impact of FIT screening on CRC incidence 48 ABSTRACT Background We aimed to predict the long-term colorectal cancer incidence, mortality, and colonoscopy demand of the recently implemented Dutch colorectal cancer screening program.

Some solid tumors are characterized by extracellular matrix (ECM) remodeling and stiffening, which is related to solid tumor progression and aggression. However, the relationship between ECM stiffness and colorectal cancer (CRC) remains unclear. In this study, we investigated the relevance of ECM stiffness to clinicopathologic features using human CRC tissue microarrays. The results demonstrate...

Emerging studies on tumor cell-derived extracellular vesicles (EVs) have shown the biological significance in tumor development and microenvironment through reprogramming immune cells around cancer cells. In this study, we used colorectal cancer cells as EVs donor, and T cells as recipients to examine whether EVs impair the T cell function. As a result, we found that colorectal cancer cell-deri...

BACKGROUND Colorectal cancer (CRC) is a leading cause of cancer death worldwide. Epidemiological risk factors for CRC included alcohol intake, which is mainly metabolized to acetaldehyde by alcohol dehydrogenase and further oxidized to acetate by aldehyde dehydrogenase; consequently, the role of genes in the alcohol metabolism pathways is of particular interest. The aim of this study is to anal...