High-performance algorithms can be found at the heart of many software systems; they often provide the key to effectively solving the computationally difficult problems encountered in the application areas in which these systems are deployed. Examples of such problems include planning, scheduling, timetabling, resource allocation, computer-aided design and software verification. Many of these p...

Computer tomography (CT) imaging plays an important role in cancer detection and quantitative assessment in clinical trials. High-resolution imaging studies on large cohorts of patients generate vast data sets, which are infeasible to analyze through manual interpretation. In this article we describe a comprehensive architecture for computer-aided detection (CAD) and surveillance on lung nodule...

Glaucoma is one of the major causes for blindness with a high rate of unreported cases. To reduce this number, screening programs are performed. However, these are characterized by a high workload for manual and cost-intensive assessment. Computer-aided diagnostics (CAD) to perform an automated pre-exclusion of normals might help to improve program’s efficiency. This chapter reviews and discuss...

A computer imaging system was introduced into the facial reconstruction process. The system, which consists of the image processing unit for skull morphometry and the image editing unit for compositing facial components on the skull images, was an original construction. The image processor generates the framework for building a face onto the digitized skull image. For reconstructing a facial im...

A numerical variational method is herein introduced for the automatic redesign of mechanical parts subject to a design change. This method is demonstrated to the design of mechanical parts in the context of concurrent engineering of 3D parts. Relations between dimensions in a mechanical part as dictated by a designer are modeled using mechanisms and their kinematic relations. Variational cut-jo...

Often in modeling the engineering optimization design problems, the value of objective function(s) is not clearly defined in terms of design variables. Instead it is obtained by some numerical analysis such as FE structural analysis, fluid mechanic analysis, and thermodynamic analysis, etc. Yet, the numerical analyses are considerably time consuming to obtain the final value of objective functi...

Early diagnosis is the most reliable solution for an effective treatment of melanoma. There is an ongoing research effort to develop computer aided imaging tools and functional content-based image retrieval systems as diagnostic support to dermatologists. Following this spirit, a Topic Map based management and retrieval system for melanoma images has been developed. Currently, this research wor...

Regional Atrophy analysis of structural magnetic resonance image (MRI) of the brain may provide quantitative evidence of different neurodegenerative diseases. This paper proposes an approach for early detection of Alzheimer disease (AD) by locating the atrophy in the brain. The paper proposes an automated computer aided system to for differential diagnosis of different neurodegenerative disease...

Follicular lymphoma (FL) is one of the most common types of non-Hodgkin's lmphomas in the world. Diagnosis of FL is based on morphological and immunohistochemical characteristics found on tissue sections. Our project's aim is to develop computer-aided analysis tools on virtual slide images (VSI) of lymphoid tissues with the purpose of improving the FL grading performed in malignant follicles. I...