For all DBMS-based software systems, a good database design is the key to perfonnance. Nevertheless the necessity to support this important task by adequate methods and comfortable tools has been neglected up to now. As a consequence at least one generation of computer progranuners fought the battle for necessary perf0J111anCe which was already lost in the beginning, lost by design. Facing this...

Increasing energy prices, tighter environmental regulation, and global competition urge the industry to optimize its processes for converting chemicals energy. This optimization is far from trivial. Often, key major breakthrough relies not only on optimal process conditions but also selecting suitable molecules as solvents, catalysts, or heat transfer fluids. selection highly coupled with itsel...

Recent clinical trials using antibodies with low toxicity and high efficiency have raised expectations for the development of next-generation protein therapeutics. However, the process of obtaining therapeutic antibodies remains time consuming and empirical. This review summarizes recent progresses in the field of computer-aided antibody development mainly focusing on antibody modeling, which i...