CBL-family ubiquitin ligases are critical negative regulators of tyrosine kinase signaling, with a clear redundancy between CBL and CBL-B evident in the immune cell and hematopoietic stem cell studies. Since CBL and CBL-B are negative regulators of immune cell activation, elimination of their function to boost immune cell activities could be beneficial in tumor immunotherapy. However, mutations...

The ubiquitin ligases CBL and CBL-B are negative regulators of tyrosine kinase signaling with established roles in the immune system. However, their physiological roles in epithelial tissues are unknown. Here, we used MMTV-Cre-mediated Cbl gene deletion on a Cbl-b null background, as well as a tamoxifen-inducible mammary stem cell (MaSC)-specific Cbl and Cbl-b double knockout (Cbl/Cbl-b DKO) us...

A pragmatic and sequential mixed method study was conducted at Army Medical College, from October to December 2014 to determine medical students' perceptions regarding effectiveness of small groups during the CBL(case-based learning) sessions. Tutorial Group Effectiveness Instrument (TGEI) was used after written and informed consent. Free text comments about CBL were invited from the respondent...

Clinical reasoning in multimorbidity conditions asks for the ability to anticipate possible evolutions of overall health state a patient and identify interactions among concurrent issues their treatments. The HIN (Health Issue Network) approach, as Petri Nets-based formal language, is introduced capable providing novel perspective facilitate acquisition such competencies, graphically representi...

<p>This paper aims to analyze the learning behavior of Thai learners by using a computer-based system for English writing. Three main objectives were set: development system, automatic data collection, and analytics. Firstly, is developed under multidisciplinary idea that designed integrate two concepts between self-regulated model components natural language processing. The integration d...

Growing evidences support the concept that peritumoral microenvironment gene expression is an important element for physicians to make an accurate prognosis. Nonetheless, the correlation between peritumoral ubiquitin ligases and the hepatocellular carcinoma (HCC) survival remains unclear till this present. The expression of intratumoral and peritumoral Casitas B-lineage Lymphoma (Cbl) and epide...

BACKGROUND Nitrosylcobalamin (NO-Cbl) is a chemotherapeutic pro-drug derived from vitamin B12 that preferentially delivers nitric oxide (NO) to tumor cells, based upon increased receptor expression. NO-Cbl induces Apo2L/TRAIL-mediated apoptosis and inhibits survival signaling in a variety of malignant cell lines. Chemotherapeutic agents often simultaneously induce an apoptotic signal and activa...

Computers have been used for language teaching ever since the 1960's.Learning a second language is a challenging endeavor, and, for decades now, proponents of computer assisted language learning (CALL) have declared that help is on the horison. We investigate the suitability of deploying speech technology in computer based systems that can be used to teach foreign language skills. In this case,...

Phagocytosis mediated by FcgammaR plays an important role in host defense. The molecular events involved in this process have not been completely defined. The adapter protein Cbl has been implicated in FcgammaR signaling, but the function of Cbl in phagocytosis is unknown. Here we show that overexpression of the transforming mutants of Cbl, Cbl-70Z, and v-Cbl, but not wild-type (wt) Cbl, enhanc...