BACKGROUND There are ongoing efforts to optimize patient selection criteria for cardiac resynchronization therapy (CRT). In this regard, the relationship between acute change in left ventricular synchrony (LV) after CRT and patient outcome remains undefined. METHODS AND RESULTS A novel protocol was designed to evaluate acute change in left LV synchrony after CRT using phase analysis of standa...

Implantation numbers of conventional antibradycardia pacemakers (PM), implantable cardioverter defibrillators (ICD) and cardiac resynchronisation therapy PMs ICDs (CRT-P D) have shown a minimal increase till 2017. Between 2017–2019 the implantation remained on steady state level, ILR, CRT-D slight increase, moreover ratio CRT-P against has decreased. Year 2020 was special year due to SARS-CoV2 ...

BACKGROUND The Seattle Heart Failure Model (SHFM) provides accurate estimates of survival in heart failure (HF) patients. The model is, however, not developed for HF patients with cardiac resynchronization therapy (CRT). The aim of this study was to assess the prognostic value of SHFM combined with QRS morphology and CRT-related change in QRS duration in implantable cardioverter defibrillator (...

BACKGROUND Clinical or echocardiographic mid-term responses to cardiac resynchronization therapy (CRT) may have a different influence on a long-term prognosis of heart failure patients treated with CRT. The aim of the evaluation was to establish which definition of response to CRT, clinical or echocardiographic, best predicts long-term prognosis. METHODS AND RESULTS A total of 679 heart failu...

BACKGROUND We have previously reported strain dyssynchrony index assessed by two-dimensional speckle tracking strain, and a marker of both dyssynchrony and residual myocardial contractility, can predict response to cardiac resynchronization therapy (CRT). A newly developed three-dimensional (3-D) speckle tracking system can quantify endocardial area change ratio (area strain), which coupled wit...

AIMS Fluctuations in left ventricular (LV) thresholds with cardiac resynchronization therapy (CRT) are unknown. The LV capture management (LVCM) algorithm automatically measures LV thresholds on a daily basis and offers the opportunity to analyse threshold fluctuations. METHODS AND RESULTS A total of 282 patients implanted with a Medtronic Concerto CRT-D device were prospectively studied. Dev...

BACKGROUND Recent studies have reported prognosis differences between male and female heart failure patients following cardiac resynchronization therapy (CRT). However, the potential clinical factors that underpin these differences remain to be elucidated. METHODS A meta-analysis was performed to investigate the factors that characterize sex-specific differences following CRT. This analysis i...

Cardiac resynchronization therapy (CRT) has come a long way from its inception as a last-ditch attempt to salvage intractable heart failure (HF) in patients with demonstrated electrical dyssynchronies to its current status as a routine mainstream therapy recommended for moderate and even mild HF. The increase in popularity of CRT is due to two main factors: large-scale randomized clinical trial...

Radiotherapy (RT) is the standard therapy for unresected stage I-II nonsmall cell lung cancer (NSCLC). Using population-based data, we compared survival and toxicity among unresected elderly patients treated with combined chemoradiotherapy (CRT) or RT alone. Using the Surveillance, Epidemiology and End Results (SEER) registry (National Cancer Institute, Bethesda, MD, USA) we identified 3,006 ca...