Mutations in the tau gene cause frontotemporal dementia with parkinsonism, presumably by affecting the balance between tau isoforms (with either three or four microtubule-binding repeats) or by impairing tau-tubulin binding. Although to date no mutations have been found for Alzheimer's disease, it is plausible that tangle pathology in this disorder is also driven by similar molecular modificati...

Abstract The viscosities of poly(3-hydroxybutyrate) (PHB) with mixed tacticities were determined as functions temperature and shearing rate via plate–plate viscosimetry, fitted by a combined Herschel–Bulkley–Cross–Doolittle model while applying Carvalho et al.’s single-point correction. They compared to values slit obtained during processing at 428 K. In both cases, measured parameters function...

The Binding Energy Distribution Analysis Method (BEDAM) is employed to compute the standard binding free energies of a series of ligands to a FK506 binding protein (FKBP12) with implicit solvation. Binding free energy estimates are in reasonably good agreement with experimental affinities. The conformations of the complexes identified by the simulations are in good agreement with crystallograph...

nbo analysis, hybrid density functional theory (b3lyp/6-311+g**) and ab initio molecular orbital (hf/6-311+g**) based methods were used to study the anomeric effects (ae), electrostatic interactions, dipole-dipole interactions and steric repulsion effects on the conformational properties of 2-methoxy- (1), 2-methylthio- (2), 2-methylseleno- (3), 2-fluoro- (4), 2-chloro- (5) and 2-bromocyclohexa...

background :co-morbid psychiatric disorders affect prognosis, psychosocial adjustment and post-surgery satisfaction in patients with gender identity disorder. in this paper, we assessed the frequency of personality disorders in iranian gid patients.   methods : seventy- three patients requesting sex reassignment surgery (srs) were recruited for this cross- sectional study. of the participants, ...

background :5httlpr polymorphism (5- hydroxytryptamine transporter linked promoter region polymorphism) is the most widely studied genetic variant in psychiatry. the present study is a modest effort at ascertaining the role of 5ht transporter linked promoter region polymorphism (5httlpr) in anxiety and depressive disorders in kashmir (india).the aim of this study was to examine 5-hydroxy trypta...

objective in this article, a motor skill disorder called developmental coordination disorder (dcd), that is usually first diagnosed during childhood, is explained and discussed. in the year 1987, dcd was formally recognized as a distinct disorder in children by the american psychiatric association  (apa). dcd is a generalized term for the children who have some degrees of impairment in the deve...

Chaperones are highly sophisticated protein machines that assist the folding of RNA molecules or other proteins. Their function is generally thought to require a fine-tuned and highly conserved structure: despite the recent recognition of the widespread occurrence of structural disorder in the proteome, this structural trait has never been generally considered in molecular chaperones. In this r...