BACKGROUND Congenital combined pituitary hormone deficiency (CPHD) is a rare heterogeneous group of conditions. CPHD-type 3 (CPHD3; MIM# 221750) is caused by recessive mutations in LHX3, a LIM-homeodomain transcription factor gene. The isoforms of LHX3 are critical for pituitary gland formation and specification of the anterior pituitary hormone-secreting cell types. They also play distinct rol...

Sudden bilateral hearing loss are seen rarely and the toxic substance exposure constitutes a small part of etiology. A Fifty-eight-year-old woman admitted to our clinic with sudden bilateral hearing loss shortly after chlorpyrifos-ethyl exposure. Otolaryngologic examination findings were normal. The patient had 40 dB sensorineural hearing loss (SNHL) on the right ear and 48 dB SNHL on the left ...

A 26-year-old man was admitted to our clinic with approximately 8 years history of hearing loss on the right side. The pathological findings were not found in the neuro-otological examination. Severity sensorinoral hearing loss (SNHL) was determined on the pure tone audiometry. The magnetic resonance imaging (MRI) and computed tomography (CT) were shown that the lipomatous lesion involved right...

Widespread use of antimicrobial drugs in the management of otitis media has significantly reduced the incidence of labyrinthitis nowadays. Cases of tympanogenic labyrinthitis following acute otitis media have rarely been reported in recent literature on otolaryngology. We report an unusual case of tympanogenic labyrinthitis that presented with sudden sensorineural hearing loss (SNHL) following ...

introduction: conductive hearing loss due to chronic otitis media (com) can be treated by surgery. com, however, may be associated with functional damage to the inner ear. sensorineural hearing loss (snhl) due to com has been found to be significant by some authors, whereas it has been considered negligible by others. the present study aimed to answer the question does com cause snhl ? methods:...

A major constraint for listeners with sensorineural hearing loss (SNHL) is the reduced acoustic dynamic range associated with loudness recruitment; however, the physiological correlates of loudness and recruitment are still not well understood. Recent psychophysical results challenge some of the classic concepts of recruitment (Buus and Florentine 2001), and suggest that the dynamic range of lo...

Mutations in mitochondrial DNA (mtDNA) have been shown to be an important cause of sensorineural hearing loss (SNHL). In this study, we performed a clinical and genetic analysis of 169 hearing-impaired patients and some of their relatives suffering from idiopathic SNHL, both familial and sporadic. The analysis of four fragments of their mtDNA identified several polymorphisms, the well known pat...

Apgar scores of 0-4 at 1 minute and 0-6 at 5 minutes have been investigated as risk criteria in the Utah High Risk Hearing Screening Program. The 1990 Joint Committee on Infant Hearing (JCIH) statement recommended only an Apgar score of 0-3 at 5 minutes be included in a risk registry for sensorineural hearing loss (SNHL). An analysis of live births indicates the more lenient Utah cut-off criter...