We disclose the synthesis, characterization, and catalytic application of a triphos-tagged, non-pincer-type tungsten complex. The pertinent W-based half-sandwich compound was used in homogeneous hydrogenation ketones esters to afford corresponding alcohols. Furthermore, introduced base metal catalyst facilitated conjugate reduction enoates yield respective CC-bond-free esters. Most applied subs...

haemophilus influenzae, a major cause of meningitis in young children leading to death and other neurological sequelae. the disease leaves 15 to 35% of the survivors with permanent disabilities, such as, mental retardation or deafness. despite the availability of new and more powerful antibiotics children with hib meningitis still suffer from high mortality or morbidity. the emergence of multir...

The humanized monoclonal antibody maytansinoid conjugate, cantuzumab mertansine (huC242-DM1) that contains on average three to four linked drug molecules per antibody molecule was evaluated in CD-1 mice for its pharmacokinetic behavior and tissue distribution, and the results were compared with those of the free antibody huC242. The pharmacokinetics in blood were similar for (125)I-labeled conj...

background: polysaccharides have long been used as immune-modulators in various pathologic conditions including inflammation and solid malignancies. objective: to evaluate the effects of zymosan and betaglucan on cytotoxic reactions in an effectortarget conjugate system. methods: blood was obtained from 20 healthy subjects; purified mononuclear leukocytes (monocytes and lymphocytes) were extrac...

OBJECTIVE The spectrum of diseases caused by Streptococcus pneumoniae and non-typeable Haemophilus influenzae (NTHi) represents a large burden on healthcare systems around the world. Meningitis, bacteraemia, community-acquired pneumonia (CAP), and acute otitis media (AOM) are vaccine-preventable infectious diseases that can have severe consequences. The health economic model presented here is i...

A condition for a statistical manifold to have an equiaffine structure is studied. The facts that dual flatness and conjugate symmetry of a statistical manifold are sufficient conditions for a statistical manifold to have an equiaffine structure were obtained in [2] and [3]. In this paper, a fact that a statistical manifold, which is conjugate Ricci-symmetric, has an equiaffine structure is giv...

The visual cycle is a series of enzyme-catalyzed reactions which converts all-trans-retinal to 11-cis-retinal for the regeneration of visual pigments in rod and cone photoreceptor cells. Although essential for vision, 11-cis-retinal like all-trans-retinal is highly toxic due to its highly reactive aldehyde group and has to be detoxified by either reduction to retinol or sequestration within ret...

The paper presents some open problems associated to the nonlinear conjugate gradient algorithms for unconstrained optimization. Mainly, these problems refer to the initial direction, the conjugacy condition, the step length computation, new formula for conjugate gradient parameter computation based on function’s values, the influence of accuracy of line search procedure, how we can take the pro...

In this paper, we propose smart step closed-loop power control (SSPC) algorithm and base station assignment based on minimizing the transmitter power (BSAMTP) technique in a direct sequence-code division multiple access (DS-CDMA) receiver in the presence of frequency-selective Rayleigh fading. This receiver consists of three stages. In the first stage, with conjugate gradient (CG) adaptive ...

in this paper, the concept of {sl local base with  stratifiedstructure} in $i$-topological vector spaces is introduced. weprove that every $i$-topological vector space has a balanced localbase with stratified structure. furthermore, a newcharacterization of $i$-topological vector spaces by means of thelocal base with stratified structure is given.