The objective of this paper is to delineate some of the advances in clinical oncology that have occurred since the 1950s in the context of methodological principles established by Dr. Emil J Freireich and colleagues. Four statistical aspects of the methodological developments in clinical trials are considered and illustrated by real examples: a quantitative approach to the design and analysis o...

background irritable bowel syndrome (ibs) is one of the common gastrointestinal disorders with unknown etiology. in experimental models, it is proposed that soy isoflavones may suppress the clinical and psychological symptoms of ibs by alteration of gut barrier tight junctions. methods we conducted this study to evaluate the effects of soy isoflavones on ibs symptoms and patients’ quality of li...

objective: this clinical trial examines the effect of augmentation of methylphenidate (mph) with folic acid to improve quality of life, and to treat aggression and adhd symptoms . method: participants of this eight week randomized double blind placebo controlled clinical trial were 49 children with adhd. they were randomly assigned into one of the two groups: the first group receiving methylphe...

conclusions the present study showed that g-csf is not superior to placebo in production of protective antibody titers after hbv vaccination but could result in a more rapid antibody response, compared to the placebo. results there was no statistically significant difference between anti-hbv antibody titers in patients receiving double dose hbv vaccination plus g-csf and patients receiving doub...

results the search criteria yielded 16 manuscripts on percutaneous adhesiolysis assessing post-surgery syndrome. of these, only 4 randomized trials met inclusion criteria for methodological quality assessment, 3 of them were of high quality; and the fourth manuscript was of low quality. based on these 3 randomized controlled trials, 2 of them with one-day procedure and one with a 3-day procedur...