Mobile Ad-hoc Network routing protocols such as AODV, DSR etc. fail in scenario in which no contemporaneous path exists between source and destination because they try to find end-toend path before data transmission which is not exist in VANET which increase delivery delay and decrease delivery ratio. So VANET uses ‘store-carry-forward’ paradigm. In network coding, source node or intermediate n...

Conventional approach for solving replenishment lot size problem is by using the differential calculus with the need of applying the first-order and second-order differentiations to the long-run average production-inventory cost. A recent published paper used conventional method to determine optimal lot size for an integrated production-delivery system with scrap and cost lessening distribution...

Ophthalmic In-situ gels are viscous polymer‐based liquids that exhibit sol‐to‐gel phase transition on the ocular surface due to change in a specific physicochemical parameter like ionic strength, pH or temperature Gel dosage forms are successfully used as drug delivery systems considering their ability to prolong the drug release. To prolong the precorneal resident time and improve ocular bioav...

Polymers have always been valuable excipients in conventional dosage forms, also have shown excellent performance into the parenteral arena, and are now capable of offering advanced and sophisticated functions such as controlled drug release and drug targeting. Advances in polymer science have led to the development of several novel drug delivery systems. Interpenetrating polymer networks (IPNs...

It is therapeutically desirable to effectively deliver ceramide, an antimitogenic and proapoptotic lipid second messenger, to transformed cell types. However, the targeted delivery of cell-permeable ceramide analogs, including C6-ceramide, to cells may be impeded by the hydrophobicity of these bioactive lipids, resulting in reduced efficacy. The objective of this study is to develop and optimiz...

Since last 15 years the number of 505(b)(2) filings with new dosage forms for existing drug molecules at United states Food and Drug Administration (USFDA) has been increased tremendously. This is because of the tremendous increase in the developmental cost of new chemical entities (NCE) and increased concerns about patient preferences and market demands for the novel unconventional dosage form...

Because of the particular characteristics of the tumor microenvironment and tumor angiogenesis, it is possible to design drug delivery systems that specifically target anti-cancer drugs to tumors. Most of the conventional chemotherapeutic agents have poor pharmacokinetics profiles and are distributed non-specifically in the body leading to systemic toxicity associated with serious side effects....

Topical drug delivery to poorly ventilated paranasal sinuses is challenging. Pulsating aerosols can improve the deposition of drugs like cortisol in sinuses. The current study compares effect Budesonid administered as pulsating aerosol comparison conventional nasal spray

In this paper, we evaluate the most optimal service delivery method that can be implemented by both governmental and private sectors to an effective customers. They include conventional delivery, E-services (online), M-services (smart phones), robotic process automation (RPA). Benefits costs were considered in evaluation process. technical feasibility, efficiency, security, reliability, innovat...

The ability of nanoparticles to manipulate the molecules and their structures has revolutionized the conventional drug delivery system. The chitosan nanoparticles, because of their biodegradability, biocompatibility, better stability, low toxicity, simple and mild preparation methods, offer a valuable tool to novel drug delivery systems in the present scenario. Besides ionotropic gelation metho...