The essential metal copper, zinc and iron content in starved virgin and pregnant rat tissue has been studied. The copper content of the whole rat, which was actually increased in pregnant rats, decreased in starved pregnant rats. The differences were significant in 19-day pregnant rats. The total copper content of the conceptus was not affected by starvation. Iron distribution and net tissue co...

We studied the mechanisms by which excess copper exerts, and zinc mitigates, toxic effects on HepG2 cells. Survival and cell growth were reduced in media containing greater than 500 microM copper chloride for 48 h; LD50 was 750 microM. At 1,000 microM copper for 1 h, there was a general reduction of protein synthesis, and no recognizable changes in cellular ultrastructure. Incubation of cells w...

Serum zinc and copper concentrations of 156 healthy children (6-12 years old) were measured by the atomic absorption spectrophotometric method. The average serum zinc concentration was 92 +/- 13 mug/100 ml (mean +/- S.D.) with a range of 62-127 mug/100 ml. No statistically significant age or sex differences were found in serum zinc levels. The mean serum copper level was 109 +/- 17 mug/100 ml w...

introduction the mahour exploration area is a polymetallic system containing copper, zinc and silver. the mineralization can be seen in two forms of veins and disseminations. this area is structurally within the lut block, west of deh-salm village. recent exploration work and studies carried out by geologists on this volcanic-plutonic area of lut demonstate its importance indicating new reserve...

Plasma copper and zinc in 20 ewes, healthy or infected with chronic postpartum metritis or mastitis, have been determined by atomic absorption spectrophotometry. Plasma protein profile was measured by electrophoresis on cellulose acetate plates, and albumin and ceruloplasmin were determined colorimetrically. For the ten initial days, plasma copper and ceruloplasmin increased in plasma zinc decr...

Sensitivity of GABAA receptors (GABARs) to inhibition by zinc and other divalent cations is influenced by the alpha subunit subtype composition of the receptor. For example, alpha6beta3gamma2L receptors are more sensitive to inhibition by zinc than alpha1beta3gamma2L receptors. We examined the role of a His residue located in the M2-M3 extracellular domain (rat alpha6 H273) in the enhanced zinc...

Information from animal studies has demonstrated the harmful effects of zinc supplementation on copper transport. Although some studies have been carried out in humans, the effect on humans has not been as well documented as the effect on animals. Forty-seven healthy volunteers (26 women and 21 men) took part in a double-blind cross-over trial which lasted for 12 weeks. The subjects were asked ...

Flotation is, doubtless, the most important process among the various techniques used for the treatment of ore. This generalpurpose technique allows the treatment of several complex ores (lead zinc, copper zinc), sulphides (copper, lead, and zinc), oxides (hematite, quartz), oxidized minerals (malachite, cerusite) and even non-metal ores (fluorite, phosphate, coal). Due to the flotation, it is ...

With the exception of calcium very little is known about metal binding characteristics of either human salivary or porcine pancreatic amylase. In order to learn more about these protein-metal binding interactions, calcium-free human salivary and porcine pancreatic amylase [P(protein)] were obtained by carboxymethylcellulose chromatography of the partially purified proteins. Because these protei...