In the present study, the effects of the acute and chronic oral administrations (po) of curcumin in the absence and presence of morphine and naloxone was investigated on the sensation of acute corneal pain in rats. Acute corneal pain was induced by the local application of hypertonic saline (5 M NaCl) on the corneal surface, and the number of eye wipes was then counted for 30 s. Subcutaneous (s...

PURPOSE To study the role of mimecan, a member of the small leucine-rich proteoglycans (SLRPs) gene family and one of the major components of the cornea and other connective tissues, mice that lack a functional mimecan gene were generated and characterized. METHODS Mimecan-deficient mice were generated by gene-targeting using standard techniques. Mice were genotyped by Southern blot analysis....

purpose: to evaluate the effect of topical phenytoin 1 % on corneal epithelial defects healing in a rabbit model. methods: one eye of 20 albino rabbits in the animal house of al-zahra ophthalmology hospital was studied. a single corneal epithelial defect was created. the rabbits were randomly assigned into two groups (ten animals in each group). after creating a chemical burn in rabbits, one gr...

PURPOSE To evaluate the clinical outcomes after implantation of the MyoRing (DIOPTEX GmBH, Linz, Austria) by means of femtosecond laser technology in eyes with corneal ectasia. DESIGN Retrospective, consecutive, nonrandomized, case series. PARTICIPANTS A total of 12 eyes of 11 patients with ages ranging from 17 to 50 years were included. All cases were diagnosed with corneal ectasia accordi...

PURPOSE. To evaluate the shape of the posterior corneal surface in eyes with normal myopia or myopic astigmatism and the changes after LASIK and epi-LASIK. METHODS. A total of 152 eyes were included in the study. The posterior corneal elevation was measured with Scheimpflug imaging (Pentacam; Oculus, Wetzlar, Germany), before LASIK or epi-LASIK and at 1 and 6 months after surgery, along the fou...

To the Editor: In their recent article, Durrie and colleagues1 reported results of lift-flap retreatment after LASIK. The authors concluded that this procedure appears to be effective and is associated with minimal complications. They reported that before reoperation, mean spherical equivalent refraction was -2.34 D (range, -0.67 to -5.75 D). The Summit Apex excimer laser (Summit Technology, Wa...

PURPOSE To model keratoconus (KC) progression and investigate the differential responses of central and eccentric cones to standard and alternative collagen cross-linking (CXL) patterns. METHODS Three-dimensional finite element models (FEMs) were generated with clinical tomography and IOP measurements. Graded reductions in regional corneal hyperelastic properties and thickness were imposed se...