Inflammation and angiogenesis are integral parts of wound healing. However, excessive and persistent wound-induced inflammation and angiogenesis in an avascular tissue such as the cornea may be associated with scarring and visual impairment. Junctional adhesion molecule A (Jam-A) is a tight junction protein that regulates leukocyte transmigration as well as fibroblast growth factor-2 (FGF-2)-in...

purpose : to present a case of typical cogan syndrome (cs) and the efficacy of topical cyclosporine a in the treatment case report : a 38-year-old woman with history of dizziness, loss of bilateral hearing and tinnitus in both ears who developed bilateral keratitis and on biomicroscopic examination, subepithelial stromal infiltration, corneal vascularization was observed in both eyes. anterior ...

PURPOSE With advances in phenotyping tools and availability of molecular characterization, an increasing number of phenotypically and genotypically diverse inherited corneal dystrophies are described. We aimed to determine the underlying causative genetic mechanism in a three-generation pedigree affected with a unique anterior membrane corneal dystrophy characterized by early onset recurrent co...

To fabricate donor corneal substitutes based on carbodiimide cross-linked porcine collagen, to study their in vitro and in vivo properties, and to elaborate new implantation techniques for the donor corneal collagen-based substitutes, this study had been performed. Bioengineered substitutes of corneal stroma (BSCS) were fabricated by cross-linking porcine type I collagen with 1-ethyl-3-(3-dimet...

PURPOSE This paper compares and evaluates the corneal morphological changes occurring after cataract surgery through a 2.2 mm corneal incision. We use two platforms for comparison and evaluation, transversal and torsional phacoemulsification. PATIENTS AND METHODS This study includes 139 consecutive cataractous eyes (nuclear color 2-4, according to the Lens Opacities Classification System III ...

The PPCD1 mouse, a spontaneous mutant that arose in our mouse colony, is characterized by an enlarged anterior chamber resulting from metaplasia of the corneal endothelium and blockage of the iridocorneal angle by epithelialized corneal endothelial cells. The presence of stratified multilayered corneal endothelial cells with abnormal patterns of cytokeratin expression are remarkably similar to ...

PURPOSE To evaluate the TGFBI gene and the encoded transforming growth factor beta-induced protein (TGFBIp) in a 47-year-old African-American patient with an unusual atypical asymmetric lattice corneal dystrophy (LCD). METHODS The eyes of the proband and his brother were examined by slit-lamp biomicroscopy and their clinical records were reviewed. All 17 exons of TGFBI were evaluated in genom...

To the Editor: The same stromal opacities found in the rabbit study by Salomão et al, 1 which appeared in the June 2011 issue of the Journal of Refractive Surgery, have been previously described as frequent but asymptom-atic complications after corneal cross-linking (CXL) in cases of steep corneas with keratometry values Ͼ54.00 diopters (D). 2-4 Raiskup et al 4 demonstrated that infusion with a...

BACKGROUND Few previous reports have described the presence of retinal refractile opacities at the macular area in patients presenting with longstanding peripheral retinal detachment. The exact nature of these opacities is unknown. CASE PRESENTATION Two patients were referred with an abnormal appearance of refractile opacities in the macular area noted during routine examination. Both were fo...