INTRODUCTION Approximately 1% of the general population have venous or arterial lower limb ulcers. These lesions can be treated with biological skin substitutes such as cadaver skin or tissue-engineered skin equivalents, but treatment fails in 25% of cases, resulting in pain and loss of patient autonomy, as well as increased morbidity and health care costs. In the treatment of corneal ulcers, a...

Introduction: Ulcerative keratitis is a common condition in horses due to their large, prominent eyes and can be potentially sight limiting if not diagnosed early and treated properly. Superficial, non-infected ulcers commonly heal rapidly; whereas stromal degradation associated with infected ulcers can rapidly progress to perforation of the cornea. This is characterized by increased proteolyti...

PURPOSE To evaluate the clinical outcome of umbilical cord patch (UCP) transplantation for deep corneal ulcers with perforations and descemetoceles. METHODS In this retrospective, noncomparative, interventional case series, 11 eyes of 11 patients with corneal perforation or descemetocele were included. The thickness and microstructure of UCP were measured. All eyes were treated with UCP and a...

Dematiaceous fungi are darkly pigmented, filamentary moulds and are common in the environment as plant saprophytes and pathogens. Incidental reports of corneal ulcers that have been caused by species of this group have appeared in the literature, but the relative importance of this species as potential comeal pathogens has not been appreciated. As a group, second to Fusarium solani and other mo...